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GRP78 anticorps (AA 525-628)

HSPA5 Reactivité: Humain, Rat, Souris, Chien WB, IF Hôte: Souris Monoclonal 40-BiP unconjugated
N° du produit ABIN968290
  • Antigène Voir toutes GRP78 (HSPA5) Anticorps
    GRP78 (HSPA5) (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5))
    Épitope
    • 26
    • 16
    • 13
    • 8
    • 7
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 525-628
    Reactivité
    • 187
    • 125
    • 107
    • 39
    • 38
    • 36
    • 34
    • 32
    • 31
    • 20
    • 16
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Rat, Souris, Chien
    Hôte
    • 132
    • 91
    • 9
    • 3
    • 1
    • 1
    Souris
    Clonalité
    • 135
    • 103
    Monoclonal
    Conjugué
    • 101
    • 21
    • 17
    • 14
    • 13
    • 12
    • 9
    • 8
    • 8
    • 8
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp GRP78 est non-conjugé
    Application
    • 223
    • 104
    • 90
    • 86
    • 78
    • 34
    • 31
    • 29
    • 26
    • 21
    • 13
    • 7
    • 6
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Chien, Rat (Rattus), Souris
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human BiP/GRP78 aa. 525-628
    Clone
    40-BiP
    Isotype
    IgG2a
    Top Product
    Discover our top product HSPA5 Anticorps primaire
  • Commentaires

    Related Products: ABIN968587, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Han, Kim, Lee, Lee, Lee, Ohba, Kuroki, Suh, Ryu: "Localization of phospholipase D1 to caveolin-enriched membrane via palmitoylation: implications for epidermal growth factor signaling." dans: Molecular biology of the cell, Vol. 13, Issue 11, pp. 3976-88, (2002) (PubMed).

    Waelter, Boeddrich, Lurz, Scherzinger, Lueder, Lehrach, Wanker: "Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation." dans: Molecular biology of the cell, Vol. 12, Issue 5, pp. 1393-407, (2001) (PubMed).

    Yamazaki, Chang, Haass, Ihara: "Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells." dans: The Journal of biological chemistry, Vol. 276, Issue 6, pp. 4454-60, (2001) (PubMed).

    Ting, Lee: "Human gene encoding the 78,000-dalton glucose-regulated protein and its pseudogene: structure, conservation, and regulation." dans: DNA (Mary Ann Liebert, Inc.), Vol. 7, Issue 4, pp. 275-86, (1988) (PubMed).

  • Antigène
    GRP78 (HSPA5) (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5))
    Autre désignation
    BiP (HSPA5 Produits)
    Synonymes
    anticorps GRP78, anticorps BiP, anticorps GRP-78, anticorps grp78, anticorps hspa5a, anticorps BIP, anticorps MIF2, anticorps AL022860, anticorps AU019543, anticorps Bip, anticorps D2Wsu141e, anticorps D2Wsu17e, anticorps Grp78, anticorps Hsce70, anticorps SEZ-7, anticorps Sez7, anticorps baffled, anticorps mBiP, anticorps cb865, anticorps fb60h09, anticorps fi36d04, anticorps wu:fb60h09, anticorps wu:fi36d04, anticorps zgc:55994, anticorps zgc:77606, anticorps 78 kDa glucose-regulated protein, anticorps heat shock protein family A (Hsp70) member 5, anticorps BiP/GRP78, anticorps glucose-regulated protein 78, anticorps putative glucose-regulated protein 78, anticorps Hsp70 family ATPase KAR2, anticorps heat shock protein family A (Hsp70) member 5 S homeolog, anticorps heat shock 70 kDa protein 5a, anticorps heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa), anticorps heat shock protein 5, anticorps heat shock protein family A member 5, anticorps CpipJ_CPIJ003550, anticorps HSPA5, anticorps grp78, anticorps LOC100533358, anticorps BiP/grp78, anticorps Tc00.1047053506585.40, anticorps Tb11.02.5450, anticorps Tb11.02.5500, anticorps LMJF_28_1200, anticorps KAR2, anticorps LOC100135840, anticorps hspa5.S, anticorps hspa5, anticorps Hspa5
    Sujet
    Synthesis of nascent proteins occurs at sites on the endoplasmic reticulum (ER) called translocons. Translocon proteins form a pore in the membrane that allow passage of the newly synthesized protein from the ribosome into the ER lumen. As the nascent protein enters the lumen, it is bound by BiP (binding protein), the major chaperone of the ER. This protein is identical to the 78kDa glucose regulated protein, GRP78. BiP binds short hydrophobic sequences of the emerging peptide and prevents denaturation or nonspecific aggregation. Hydrolysis of ATP by BiP results in the release of the nascent protein which quickly assumes its proper conformation. However, if folding is incorrect, BiP again binds the protein and prevents its exit from the ER. In addition, BiP binding is thought to enhance the movement of secretory polypeptides across the ER membrane, but it is not required for protein translocation. It is 60% identical to Hsp70 and is similarly increased by conditions that produce incorrectly folded proteins. Thus, BiP is a chaperone of the ER lumen that binds misfolded or unassembled secretory proteins and ensures proper movement of proteins from the ER to the Golgi apparatus.
    Poids moléculaire
    78 kDa
    Pathways
    Thyroid Hormone Synthesis, ER-Nucleus Signaling
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