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ITGA3 anticorps (AA 110-325)

ITGA3 Reactivité: Souris, Rat, Chien WB, IF Hôte: Souris Monoclonal 42-CD49c unconjugated
N° du produit ABIN968338
  • Antigène Voir toutes ITGA3 Anticorps
    ITGA3 (Integrin, alpha 3 (ITGA3))
    Épitope
    • 16
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 110-325
    Reactivité
    • 58
    • 36
    • 17
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Souris, Rat, Chien
    Hôte
    • 46
    • 24
    • 3
    • 1
    Souris
    Clonalité
    • 50
    • 27
    Monoclonal
    Conjugué
    • 36
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ITGA3 est non-conjugé
    Application
    • 44
    • 36
    • 22
    • 14
    • 13
    • 9
    • 9
    • 8
    • 7
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Rat (Rattus), Chien
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Mouse VLA-3alpha aa. 110-325
    Clone
    42-CD49c
    Isotype
    IgG1
    Top Product
    Discover our top product ITGA3 Anticorps primaire
  • Commentaires

    Related Products: ABIN968547, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Takeuchi, Hirano, Tsuji, Osawa, Irimura: "cDNA cloning of mouse VLA-3 alpha subunit." dans: Journal of cellular biochemistry, Vol. 57, Issue 2, pp. 371-7, (1995) (PubMed).

    Takada, Murphy, Pil, Chen, Ginsberg, Hemler: "Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen." dans: The Journal of cell biology, Vol. 115, Issue 1, pp. 257-66, (1991) (PubMed).

  • Antigène
    ITGA3 (Integrin, alpha 3 (ITGA3))
    Autre désignation
    CD49c (ITGA3 Produits)
    Synonymes
    anticorps CD49C, anticorps GAP-B3, anticorps GAPB3, anticorps ILNEB, anticorps MSK18, anticorps VCA-2, anticorps VL3A, anticorps VLA3a, anticorps ITGA3, anticorps AA407068, anticorps integrin subunit alpha 3, anticorps integrin subunit alpha 3 S homeolog, anticorps integrin alpha 3, anticorps ITGA3, anticorps itga3.S, anticorps Itga3
    Sujet
    Integrins are a family of dimeric proteins that mediate cell-to-cell and extracellular matrix adhesion. They consist of a large alpha chain that is non-covalently associated with a smaller beta chain which defines the integrin subfamilies. VLA-3 (Very Late Antigen-3), a member of the integrin superfamily, exhibits elevated expression on B lymphocytes, but is also found on monocytes, platelets, and hematopoietic progenitor cells. A heterodimer of alpha3 (CD49c) and beta1 (CD29) subunits, VLA is a receptor for laminin, fibronectin, and collagen. The alpha3 chain contains a large extracellular domain with three putative metal-binding sequences, a transmembrane domain, and a short cytoplasmic tail. Differing requirements for divalent cations and the influence of RGD peptides results in multiple ligand-binding mechanisms for VLA-3. Although its expression is restricted in normal tissues, VLA-3 is found on a variety of cultured tumor cells. In addition, levels of VLA-3 have been shown to correlate with the degree of invasiveness of malignant melanoma cells. Thus, VLA-3 mediates intercellular adhesion and cell migration in normal and, possibly, cancerous cell types.
    Synonyms: Integrin alpha3, VLA-3alpha
    Poids moléculaire
    135 kDa
    Pathways
    CXCR4-mediated Signaling Events, Integrin Complex
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