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ARNT anticorps (AA 461-574)

ARNT Reactivité: Humain, Souris, Rat WB, IF Hôte: Souris Monoclonal 29-HIF unconjugated
N° du produit ABIN968355
  • Antigène Voir toutes ARNT Anticorps
    ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT))
    Épitope
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 461-574
    Reactivité
    • 56
    • 22
    • 20
    • 9
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 43
    • 13
    • 3
    Souris
    Clonalité
    • 38
    • 21
    Monoclonal
    Conjugué
    • 45
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp ARNT est non-conjugé
    Application
    • 41
    • 13
    • 13
    • 11
    • 11
    • 7
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Souris, Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human HIF-1beta/ARNT1 aa. 461-574
    Clone
    29-HIF
    Isotype
    IgG1
    Top Product
    Discover our top product ARNT Anticorps primaire
  • Commentaires

    Related Products: ABIN968537, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Ambrosini, Nath, Sierra-Honigmann, Flores-Riveros: "Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1." dans: The Journal of biological chemistry, Vol. 277, Issue 37, pp. 34601-9, (2002) (PubMed).

    Jiang, Jiang, Zheng, Lu, Hunter, Vogt: "Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1." dans: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 12, Issue 7, pp. 363-9, (2001) (PubMed).

    Suzuki, Tomida, Tsuruo: "Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia." dans: Oncogene, Vol. 20, Issue 41, pp. 5779-88, (2001) (PubMed).

    Maltepe, Schmidt, Baunoch, Bradfield, Simon: "Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT." dans: Nature, Vol. 386, Issue 6623, pp. 403-7, (1997) (PubMed).

    Drutel, Kathmann, Heron, Schwartz, Arrang: "Cloning and selective expression in brain and kidney of ARNT2 homologous to the Ah receptor nuclear translocator (ARNT)." dans: Biochemical and biophysical research communications, Vol. 225, Issue 2, pp. 333-9, (1996) (PubMed).

  • Antigène
    ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT))
    Autre désignation
    HIF-1beta (ARNT Produits)
    Synonymes
    anticorps HIF-1-beta, anticorps HIF-1beta, anticorps HIF1-beta, anticorps HIF1B, anticorps HIF1BETA, anticorps TANGO, anticorps bHLHe2, anticorps D3Ertd557e, anticorps Drnt, anticorps ESTM42, anticorps Hif1b, anticorps W08714, anticorps mKIAA4051, anticorps Arnt1, anticorps ARNT, anticorps zgc:136664, anticorps arnt1, anticorps hif1b, anticorps tango, anticorps xArnt, anticorps hif1beta, anticorps hif-1beta, anticorps arnt.2, anticorps MGC68805, anticorps aryl hydrocarbon receptor nuclear translocator, anticorps aryl hydrocarbon receptor nuclear translocator S homeolog, anticorps ARNT, anticorps Arnt, anticorps arnt, anticorps arnt.S
    Sujet
    The Ah-receptor (AHR) is a ligand activated transcription factor that mediates the biological effects of agonists. AHR dimerizes with a structurally related protein known as ARNT (arylhydrocarbon-receptor nuclear transducer). This heterodimer binds enhancer elements and induces the expression of target genes, specifically those involved in the metabolism of xenobiotics. ARNT1 and ARNT2 are members of the basic-helix-loop-helix-PAS family of heterodimeric transcription factors, which also includes AHR, hypoxia-inducible factor-1alpha (HIF-1alpha), and the Drosophila single-minded protein (Sim). While ARNT2 expression is limited to brain and kidney, ARNT1 exhibits ubiquitous expression. A targeted disruption of the Arnt locus in the mouse yields embryonic stem cells that fail to activate genes that normally respond to low oxygen tension. Arnt -/- embryos do not survive and show defective angiogenesis of the yolk sac and branchial arches, stunted development, and wasting. Thus, in addition to its regulation of xenobiotic metabolism genes, ARNT is thought to induce developmental gene expression resulting in vascularization of the developing embryo.
    Poids moléculaire
    95 kDa
    Pathways
    Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, L'effet Warburg
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