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TGFB1I1 anticorps (AA 73-186)

TGFB1I1 Reactivité: Humain, Souris, Rat, Chien WB, IF Hôte: Souris Monoclonal 34-Hic unconjugated
N° du produit ABIN968401
  • Antigène Voir toutes TGFB1I1 Anticorps
    TGFB1I1 (Transforming Growth Factor beta 1 Induced Transcript 1 (TGFB1I1))
    Épitope
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 73-186
    Reactivité
    • 35
    • 19
    • 19
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Humain, Souris, Rat, Chien
    Hôte
    • 32
    • 4
    Souris
    Clonalité
    • 33
    • 3
    Monoclonal
    Conjugué
    • 25
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TGFB1I1 est non-conjugé
    Application
    • 22
    • 13
    • 11
    • 8
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Rat (Rattus), Humain, Chien
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Mouse Hic-5 aa. 73-186
    Clone
    34-Hic
    Isotype
    IgG1
    Top Product
    Discover our top product TGFB1I1 Anticorps primaire
  • Commentaires

    Related Products: ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Wang, Yang, Guo, Sampson, Hsu, Tsai, Yeh, Wu, Guo, Chang: "Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator." dans: The Journal of biological chemistry, Vol. 277, Issue 18, pp. 15426-31, (2002) (PubMed).

    Jia, Ransom, Shibanuma, Liu, Welsh, Smoyer: "Identification and characterization of hic-5/ARA55 as an hsp27 binding protein." dans: The Journal of biological chemistry, Vol. 276, Issue 43, pp. 39911-8, (2001) (PubMed).

    Matsuya, Sasaki, Aoto, Mitaka, Nagura, Ohba, Ishino, Takahashi, Suzuki, Sasaki: "Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions." dans: The Journal of biological chemistry, Vol. 273, Issue 2, pp. 1003-14, (1998) (PubMed).

    Shibanuma, Mashimo, Kuroki, Nose: "Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence." dans: The Journal of biological chemistry, Vol. 269, Issue 43, pp. 26767-74, (1994) (PubMed).

  • Antigène
    TGFB1I1 (Transforming Growth Factor beta 1 Induced Transcript 1 (TGFB1I1))
    Autre désignation
    Hic-5 (TGFB1I1 Produits)
    Synonymes
    anticorps TGFB1I1, anticorps hic5, anticorps ara55, anticorps hic-5, anticorps tsc-5, anticorps ARA55, anticorps HIC-5, anticorps HIC5, anticorps TSC-5, anticorps Hic5, anticorps Ara55, anticorps Hic-5, anticorps ara-55, anticorps transforming growth factor beta 1 induced transcript 1, anticorps transforming growth factor beta 1 induced transcript 1 L homeolog, anticorps TGFB1I1, anticorps tgfb1i1, anticorps Tgfb1i1, anticorps tgfb1i1.L
    Sujet
    Focal adhesions are cell structures terminal to the actin-stress fiber bundles. They attach cultured cells to their substratum or extracellular matrix. These adhesions occur through the integrin receptor molecules which link cytoskeletal proteins and extracellular matrix. The intracellular adhesion is composed of a number of proteins such as paxillin, VASP, vinculin, and the focal-adhesion kinases FAK and PYK2/CAKbeta. Hic-5, also described as hydrogen peroxide inducible-mRNA, is a focal adhesion protein that binds to FAK and PYK2. It is ubiquitously expressed with the highest levels found in lung, spleen, and heart. Induction of Hic-5 is accomplished by hydrogen peroxide or TGFbeta1 and is repressed in K-ras transformed cells. Like paxillin, Hic-5 is tyrosine phosphorylated in Src-transformed cells and is highly similar to paxillin in its primary structure. Both proteins contain LIM domains and LD motifs. In addition, Hic-5 localizes to focal adhesions and co-immunoprecipitates with PYK2/CAKbeta in vivo. Thus, Hic-5 may be a substrate for CAKbeta and play a role in signal transduction during proliferation, cell motility, and adhesion.
    Poids moléculaire
    50 kDa
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway, VEGF Signaling
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