Glucocorticoid Receptor anticorps (AA 176-289)

N° du produit ABIN968431

Détail du produit anti-Glucocorticoid Receptor anticorps

Antigène: Glucocorticoid Receptor (NR3C1) (Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))

Épitope: AA 176-289

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Glucocorticoid Receptor est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), BioImaging (BI)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human Glucocorticoid Receptor alpha aa. 176-289

Clone: 41-Glucocorticoid Receptor

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN967389, ABIN968535

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-Glucocorticoid Receptor (ABIN968431)

Reichardt, Kaestner, Tuckermann, Kretz, Wessely, Bock, Gass, Schmid, Herrlich, Angel, Schütz: "DNA binding of the glucocorticoid receptor is not essential for survival." dans: Cell, Vol. 93, Issue 4, pp. 531-41, (1998) (PubMed).

Beato, Herrlich, Schütz: "Steroid hormone receptors: many actors in search of a plot." dans: Cell, Vol. 83, Issue 6, pp. 851-7, (1996) (PubMed).

Hollenberg, Weinberger, Ong, Cerelli, Oro, Lebo, Thompson, Rosenfeld, Evans: "Primary structure and expression of a functional human glucocorticoid receptor cDNA." dans: Nature, Vol. 318, Issue 6047, pp. 635-41, (1986) (PubMed).

Détails sur Glucocorticoid Receptor

Antigène: Glucocorticoid Receptor (NR3C1) (Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))

Autre désignation: Glucocorticoid Receptor (NR3C1 Produits)

Synonymes: anticorps GR, anticorps gcr, anticorps grl, anticorps xGR, anticorps gccr, anticorps gr, anticorps zgc:113038, anticorps NR3C1, anticorps GCL, anticorps LOC100302444, anticorps Gcr, anticorps Grl, anticorps Grl-1, anticorps Grl1, anticorps GRL, anticorps GCCR, anticorps GCR, anticorps NO, anticorps GR-A, anticorps nr3c1, anticorps nuclear receptor subfamily 3 group C member 1, anticorps nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), anticorps nuclear receptor subfamily 3, group C, member 1, anticorps glucocorticoid receptor, anticorps NR3C1, anticorps nr3c1, anticorps LOC100302444, anticorps Nr3c1

Sujet: Steroid hormone receptors are hormone activated transcriptional regulators that influence genes required for embryonic development and adult homeostasis. One member of the steroid hormone family is the glucocorticoid receptor. It contains AF1 and AF2 transactivation domains, a DNA binding domain, and ligand binding domain. Ligand bound glucocorticoid receptors dimerize at specific palindromic sequences called glucocorticoid response elements (GREs) in the cis-regulatory region of target genes. Both AF1 and AF2 may be important for initiation or regulation of transcription by interacting with components of the initiation complex or other intermediary factors. In addition to transactivation, glucocorticoid receptors may also regulate transcription through transrepression of target genes. Although mechanisms of transrepression are not completely understood, DNA binding alone, DNA binding plus interaction with other transcription factors, or protein-protein interaction without DNA binding are mechanisms that have been implicated. Thus, glucocorticoid receptors function in the regulation of specific genes that are essential for human development and homeostasis. This antibody is routinely tested by western blot analysis.

Poids moléculaire: 94 kDa

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Muscle Cell Differentiation, Regulation of Carbohydrate Metabolic Process