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STAT6 anticorps (C-Term)

STAT6 Reactivité: Humain, Souris, Rat WB, IF Hôte: Souris Monoclonal 23-Stat6 unconjugated
N° du produit ABIN968455
  • Antigène Voir toutes STAT6 Anticorps
    STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
    Épitope
    • 43
    • 16
    • 13
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 141
    • 78
    • 62
    • 10
    • 10
    • 9
    • 7
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 113
    • 31
    • 4
    • 1
    Souris
    Clonalité
    • 101
    • 47
    Monoclonal
    Conjugué
    • 82
    • 7
    • 7
    • 7
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp STAT6 est non-conjugé
    Application
    • 74
    • 44
    • 43
    • 27
    • 26
    • 26
    • 25
    • 19
    • 18
    • 11
    • 9
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Souris, Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human Stat6 C-terminal Recombinant Protein
    Clone
    23-Stat6
    Isotype
    IgG1
    Top Product
    Discover our top product STAT6 Anticorps primaire
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Waite, Floyd, Arbour-Reily, Stephens: "Interferon-gamma-induced regulation of peroxisome proliferator-activated receptor gamma and STATs in adipocytes." dans: The Journal of biological chemistry, Vol. 276, Issue 10, pp. 7062-8, (2001) (PubMed).

    Xia, Salzler, Kunz, Baer, Kazim, Baumann, Wetzler: "A novel serine-dependent proteolytic activity is responsible for truncated signal transducer and activator of transcription proteins in acute myeloid leukemia blasts." dans: Cancer research, Vol. 61, Issue 4, pp. 1747-53, (2001) (PubMed).

    Bartoli, Gu, Tsai, Venema, Brooks, Marrero, Caldwell: "Vascular endothelial growth factor activates STAT proteins in aortic endothelial cells." dans: The Journal of biological chemistry, Vol. 275, Issue 43, pp. 33189-92, (2000) (PubMed).

    Bromberg, Darnell: "The role of STATs in transcriptional control and their impact on cellular function." dans: Oncogene, Vol. 19, Issue 21, pp. 2468-73, (2000) (PubMed).

    Dent, Hu-Li, Paul, Staudt: "T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 23, pp. 13823-8, (1998) (PubMed).

    Heim: "The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus." dans: European journal of clinical investigation, Vol. 26, Issue 1, pp. 1-12, (1996) (PubMed).

    Mikita, Campbell, Wu, Williamson, Schindler: "Requirements for interleukin-4-induced gene expression and functional characterization of Stat6." dans: Molecular and cellular biology, Vol. 16, Issue 10, pp. 5811-20, (1996) (PubMed).

    Hou, Schindler, Henzel, Ho, Brasseur, McKnight: "An interleukin-4-induced transcription factor: IL-4 Stat." dans: Science (New York, N.Y.), Vol. 265, Issue 5179, pp. 1701-6, (1994) (PubMed).

  • Antigène
    STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
    Autre désignation
    Stat6 (STAT6 Produits)
    Synonymes
    anticorps D12S1644, anticorps IL-4-STAT, anticorps STAT6B, anticorps STAT6C, anticorps signal transducer and activator of transcription 6, anticorps signal transducer and activator of transcription 6-like, anticorps STAT6, anticorps Stat6, anticorps LOC100859543
    Sujet
    STATs (signal transducers and activators of transcription) are critical mediators of the biologic activity of cytokines including Interleukins (IL) 2-5, IL-7, IL-15, GM-CSF, erythropoietin and growth hormone. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of STATs by tyrosine phosphorylation. Active STATs then move to the nucleus to promote transcription of cytokine-inducible genes. Seven STAT proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat6 plays an important role in signaling pathways that lead to the differentiation of T helper type 2 (Th2) cells from uncommitted CD4 T cell precursors. Moreover, IL-4, secreted by activated T lymphocytes, basophils, and mast cells, induces specific gene expression via the induction of tyrosine phosphorylation of Stat6 at tyrosine 641 (Y641). The SH3:SH2 domain of Stat6 associates with tyrosine-phosphorylated IL-4 receptor and the proximal Jak kinase phosphorylates Stat6 at Y641 on the C-terminal side of the SH2 domain. Stat6 is then released from the receptor, dimerizes, and is thought to contact the basal transcription machinery by binding to p300/CBP. While Stat6 is widely expressed in human tissues, it exhibits elevated expression in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta.
    The 23/Stat6 monoclonal antibody recognizes Stat6, regardless of phosphorylation status.
    Poids moléculaire
    100 kDa
    Pathways
    Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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