CAMK2A anticorps (AA 448-460)

N° du produit ABIN968457

Détail du produit anti-CAMK2A anticorps

Antigène: CAMK2A (Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A))

Épitope: AA 448-460

Reactivité: Humain, Souris, Rat, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CAMK2A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), BioImaging (BI)

Réactivité croisée: Souris, Humain, Chien

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Rat CaM Kinase IIalpha aa. 448-460

Clone: 45-CaM Kinase II

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN967389, ABIN968545

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-CAMK2A (ABIN968457)

Fallon, Moreau, Croft, Labib, Gu, Fon: "Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain." dans: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 486-91, (2002) (PubMed).

Zong, Ren, Young, Pypaert, Mu, Birnbaum, Shulman: "AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 25, pp. 15983-7, (2002) (PubMed).

Brocke, Chiang, Wagner, Schulman: "Functional implications of the subunit composition of neuronal CaM kinase II." dans: The Journal of biological chemistry, Vol. 274, Issue 32, pp. 22713-22, (1999) (PubMed).

Ishida, Fujisawa: "Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain." dans: The Journal of biological chemistry, Vol. 270, Issue 5, pp. 2163-70, (1995) (PubMed).

Hanson, Schulman: "Neuronal Ca2+/calmodulin-dependent protein kinases." dans: Annual review of biochemistry, Vol. 61, pp. 559-601, (1992) (PubMed).

Détails sur CAMK2A

Antigène: CAMK2A (Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A))

Autre désignation: CaM Kinase II (CAMK2A Produits)

Sujet: Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) is a multifunctional Ser/Thr kinase that regulates a number of cellular functions in response to increased intracellular Ca2+. CaM kinase II is widely distributed, but is predominantly expressed in brain. It is involved in the regulation of neuronal functions such as neurotransmitter synthesis, neurotransmitter release, long-term potentiation, and formation of spatial learning. Neuronal CaM kinase II contains heteromers of two major subunits, alpha and beta, at a ratio of 2:1 and homomers of alpha subunits. Each subunit has N-terminal ATP-binding and catalytic/regulatory domains and a C-terminal association domain. The regulatory domain consists of the autoinhibitory and calmodulin-binding sites. Assembly of the association domains of multiple subunits positions the regulatory domains for intersubunit autophosphorylation. After binding Ca2+/calmodulin, CaM kinase II undergoes rapid autophosphorylation of the alpha and beta subunits, which results in a substantial increase in its affinity for Ca2+/calmodulin.
Synonyms: Ca2+/calmodulin-dependent protein kinase II

Poids moléculaire: 52 kDa

Pathways: Signalisation WNT, Interferon-gamma Pathway, Myometrial Relaxation and Contraction