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HAP1 anticorps (AA 100-289)

HAP1 Reactivité: Souris, Rat WB, IF Hôte: Souris Monoclonal 1-HAP1 unconjugated
N° du produit ABIN968461
  • Antigène Voir toutes HAP1 Anticorps
    HAP1 (Huntingtin Associated Protein 1 (HAP1))
    Épitope
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 100-289
    Reactivité
    • 13
    • 5
    • 4
    Souris, Rat
    Hôte
    • 12
    • 3
    • 2
    Souris
    Clonalité
    • 15
    • 2
    Monoclonal
    Conjugué
    • 14
    • 1
    • 1
    • 1
    Cet anticorp HAP1 est non-conjugé
    Application
    • 13
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Souris
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Rat HAP1-A aa. 100-289
    Clone
    1-HAP1
    Isotype
    IgG1
  • Commentaires

    Related Products: ABIN968545, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Li, Chin, Levey, Li: "Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking." dans: The Journal of biological chemistry, Vol. 277, Issue 31, pp. 28212-21, (2002) (PubMed).

    Gutekunst, Li, Yi, Ferrante, Li, Hersch: "The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 18, Issue 19, pp. 7674-86, (1998) (PubMed).

    Li, Hosseini, Gutekunst, Hersch, Ferrante, Li: "A human HAP1 homologue. Cloning, expression, and interaction with huntingtin." dans: The Journal of biological chemistry, Vol. 273, Issue 30, pp. 19220-7, (1998) (PubMed).

    Li, Sharp, Li, Dawson, Snyder, Ross: "Huntingtin-associated protein (HAP1): discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 10, pp. 4839-44, (1996) (PubMed).

    Li, Li, Sharp, Nucifora, Schilling, Lanahan, Worley, Snyder, Ross: "A huntingtin-associated protein enriched in brain with implications for pathology." dans: Nature, Vol. 378, Issue 6555, pp. 398-402, (1995) (PubMed).

  • Antigène
    HAP1 (Huntingtin Associated Protein 1 (HAP1))
    Autre désignation
    HAP1 (HAP1 Produits)
    Synonymes
    anticorps HAP2, anticorps HIP5, anticorps HLP, anticorps hHLP1, anticorps HAP1-A, anticorps HAP1-B, anticorps HAP-1, anticorps huntingtin associated protein 1, anticorps huntingtin-associated protein 1, anticorps HAP1, anticorps Hap1
    Sujet
    Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an expanding polyglutamine repeat in the IT15 or huntingtin gene. The mechanism(s) of pathogenesis are not known and the wide expression of Huntingtin protein does not explain the selective neuropathology of HD. HAP-1 (Huntingtin-associated protein 1), identified by yeast two hybrid screening, interacts with the huntingtin protein. There are two isoforms of rat HAP1 (HAP1-A and HAP1-B) which differ in the length of their C-terminal regions. Both proteins are highly hydrophilic and their binding to the Huntingtin protein is enhanced by the expanded polyglutamine repeat. Human HAP1 shares 62% amino acid identity with HAP1-A. HAP1 is specifically expressed in the CNS where it is restricted to limbic structures, such as amygdala, hypothalamus, bed nucleus of the stria terminalis, and the septal nucleus. The subcellular association of HAP1 with microtubules and many types of membraneous organelles implicates it in vesicular transport. Thus, the specific neural interaction of HAP1 with Huntingtin protein may lead to abnormalities in vesicular transport that cause the neuropathology of HD. This antibody is routinely tested by western blot analysis.
    Synonyms: Huntingtin Associated Protein 1
    Poids moléculaire
    85/98 kDa
    Pathways
    Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus
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