ube3a anticorps (AA 501-712)
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- Antigène Voir toutes ube3a Anticorps
- ube3a (Ubiquitin Protein Ligase E3A (ube3a))
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Épitope
- AA 501-712
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Reactivité
- Humain, Souris
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp ube3a est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Réactivité croisée
- Humain
- Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Mouse UBE3A aa. 501-712
- Clone
- 13-UBE3A
- Isotype
- IgG1
- Top Product
- Discover our top product ube3a Anticorps primaire
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- Commentaires
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Related Products: ABIN968584, ABIN967389
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store undiluted at -20° C.
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The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily." dans: Molecular and cellular biology, Vol. 19, Issue 2, pp. 1182-9, (1999) (PubMed).
: "De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome." dans: Nature genetics, Vol. 15, Issue 1, pp. 74-7, (1997) (PubMed).
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The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily." dans: Molecular and cellular biology, Vol. 19, Issue 2, pp. 1182-9, (1999) (PubMed).
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- Antigène
- ube3a (Ubiquitin Protein Ligase E3A (ube3a))
- Autre désignation
- UBE3A (ube3a Produits)
- Synonymes
- anticorps ANCR, anticorps AS, anticorps E6-AP, anticorps EPVE6AP, anticorps HPVE6A, anticorps DDBDRAFT_0188760, anticorps DDBDRAFT_0302447, anticorps DDB_0188760, anticorps DDB_0302447, anticorps ube3a, anticorps im:7140733, anticorps zgc:92173, anticorps 4732496B02, anticorps 5830462N02Rik, anticorps A130086L21Rik, anticorps Hpve6a, anticorps mKIAA4216, anticorps As, anticorps CG6190, anticorps Dmel\\CG6190, anticorps Dube3a, anticorps UBE3A, anticorps dUBE3A, anticorps das, anticorps dube3A, anticorps dube3a, anticorps MGC69536, anticorps UME3A, anticorps ubiquitin protein ligase E3A, anticorps ubiquitin-protein ligase E3A, anticorps Ubiquitin protein ligase E3A, anticorps ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) S homeolog, anticorps ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome), anticorps UBE3A, anticorps ube3a, anticorps LOC100194730, anticorps Ube3a, anticorps ube3a.S, anticorps Eint_040430
- Sujet
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Protein ubiquitination is the end product of a multienzyme cascade that involves sequential thiol-ester bond interactions between ubiquitin and enzymes termed E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin protein ligases. UBE3A (human papilloma virus E6-associated protein, E6-AP) is an E3 ubiquitin protein ligase that is linked to the neurological disorder Angelman syndrome. It mediates the interaction of human papilloma virus types 16 and 18 E6 proteins with p53, which targets p53 to the ubiquitination-proteasome degradation pathway. The C-terminal region of UBE3A contains a hect domain, which is found in many E3 ubiquitin protein ligases, while the central region contains an E6 binding region. UBE3A is expressed in the cytoplasm and nucleus of many tissues. The interaction of UBE3A with the progesterone receptor coactivates transciptional activity of the receptor in the presence of bound hormone. Thus, UBE3A is an essential component of the ubiquitination degradation pathway and the nuclear hormone receptor signal transduction pathways. This antibody is routinely tested by western blot analysis.
Synonyms: Ubiquitin Protein Ligase 3A - Poids moléculaire
- 100 kDa
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway
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