SLC3A2 anticorps (AA 9-204)

N° du produit ABIN968570

Détail du produit anti-SLC3A2 anticorps

Antigène: SLC3A2 (Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2))

Épitope: AA 9-204

Reactivité: Chemical

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SLC3A2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Rat 4F2 hc aa. 9-204

Clone: 30-CD98HC

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN967389, ABIN968548

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-SLC3A2 (ABIN968570)

Nakamura, Sato, Yang, Miyagawa, Harasaki, Tomita, Matsuoka, Noma, Iwai, Minato: "4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer." dans: The Journal of biological chemistry, Vol. 274, Issue 5, pp. 3009-16, (1999) (PubMed).

Tsurudome, Ito, Takebayashi, Okumura, Nishio, Kawano, Kusagawa, Komada, Ito: "Cutting edge: primary structure of the light chain of fusion regulatory protein-1/CD98/4F2 predicts a protein with multiple transmembrane domains that is almost identical to the amino acid transporter E16." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 5, pp. 2462-6, (1999) (PubMed).

Kanai, Segawa, Miyamoto, Uchino, Takeda, Endou: "Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)." dans: The Journal of biological chemistry, Vol. 273, Issue 37, pp. 23629-32, (1998) (PubMed).

Fenczik, Sethi, Ramos, Hughes, Ginsberg: "Complementation of dominant suppression implicates CD98 in integrin activation." dans: Nature, Vol. 390, Issue 6655, pp. 81-5, (1997) (PubMed).

Détails sur SLC3A2

Antigène: SLC3A2 (Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2))

Autre désignation: CD98HC (SLC3A2 Produits)

Synonymes: anticorps 4F2, anticorps 4F2HC, anticorps 4T2HC, anticorps CD98, anticorps CD98HC, anticorps MDU1, anticorps NACAE, anticorps Mdu1, anticorps MGC53951, anticorps slc3a2, anticorps MGC53965, anticorps SLC3A2, anticorps AI314110, anticorps Cd98, anticorps Ly-10, anticorps Ly-m10, anticorps Ly10, anticorps Mgp-2hc, anticorps fc65h12, anticorps wu:fc65h12, anticorps id:ibd1327, anticorps sb:cb519, anticorps wu:fe14a07, anticorps wu:fq18d12, anticorps zgc:55813, anticorps solute carrier family 3 member 2, anticorps solute carrier family 3 (amino acid transporter heavy chain), member 2 L homeolog, anticorps solute carrier family 3 (amino acid transporter heavy chain), member 2 S homeolog, anticorps solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2, anticorps solute carrier family 3 (amino acid transporter heavy chain), member 2a, anticorps solute carrier family 3 (amino acid transporter heavy chain), member 2b, anticorps SLC3A2, anticorps Slc3a2, anticorps slc3a2.L, anticorps slc3a2.S, anticorps slc3a2a, anticorps slc3a2b

Classe de substances: Chemical

Sujet: 4F2 antigen (CD98) was identified as a heterodimer consisting of an 80 kDa type II glycosylated integral membrane protein 4F2 heavy chain (4F2 hc) linked by disulfide bonds to a hydrophobic, non-glycosylated, 37 kDa protein 4F2 light chain (4F2 lc). The 4F2 hc colocalizes with cadherins at cell adhesion sites and is required for the intracellular targeting of 4F2 heterodimers. 4F2 hc also associates with beta1 integrins and overexpression of 4F2 reverses the suppression of beta1 integrin activation caused by overexpression of beta1 cytoplasmic domains. 4F2 has also been identified as a fusion regulatory protein FRP-1, since anti-FRP-1 antibodies can induce HIV-mediated cell fusion via an integrin system. 4F2 heterodimers are also important for activation of amino acid transport. 4F2 hc is 30% homologous with the amino acid transport activator D2/rBAT and expression of 4F2 hc in Xenopus oocytes induces system y+L amino acid transport. Thus, 4F2 hc may participate in intracellular trafficking and activation of amino acid transporters, as well as in the regulation of integrin signaling.
Synonyms: 4F2 hc

Poids moléculaire: 80 kDa