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AKAP9 anticorps (AA 17-130)

AKAP9 Reactivité: Humain WB, IF Hôte: Souris Monoclonal 7-AKAP450 unconjugated
N° du produit ABIN968571
  • Antigène Voir toutes AKAP9 Anticorps
    AKAP9 (A Kinase (PRKA) Anchor Protein (Yotiao) 9 (AKAP9))
    Épitope
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 17-130
    Reactivité
    • 22
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 18
    • 2
    • 2
    Souris
    Clonalité
    • 20
    • 2
    Monoclonal
    Conjugué
    • 12
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp AKAP9 est non-conjugé
    Application
    • 10
    • 9
    • 5
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human AKAP450 aa. 17-130
    Clone
    7-AKAP450
    Isotype
    IgG1
    Top Product
    Discover our top product AKAP9 Anticorps primaire
  • Commentaires

    Related Products: ABIN968537, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Westphal, Tavalin, Lin, Alto, Fraser, Langeberg, Sheng, Scott: "Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex." dans: Science (New York, N.Y.), Vol. 285, Issue 5424, pp. 93-6, (1999) (PubMed).

    Witczak, Skålhegg, Keryer, Bornens, Taskén, Jahnsen, Orstavik: "Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450." dans: The EMBO journal, Vol. 18, Issue 7, pp. 1858-68, (1999) (PubMed).

    Lin, Wyszynski, Madhavan, Sealock, Kim, Sheng: "Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 18, Issue 6, pp. 2017-27, (1998) (PubMed).

  • Antigène
    AKAP9 (A Kinase (PRKA) Anchor Protein (Yotiao) 9 (AKAP9))
    Autre désignation
    AKAP450 (AKAP9 Produits)
    Synonymes
    anticorps AKAP-9, anticorps AKAP350, anticorps AKAP450, anticorps CG-NAP, anticorps HYPERION, anticorps LQT11, anticorps MU-RMS-40.16A, anticorps PPP1R45, anticorps PRKA9, anticorps YOTIAO, anticorps 5730481H23Rik, anticorps AW545847, anticorps C79026, anticorps mKIAA0803, anticorps Gisp, anticorps Yotiao, anticorps AKAP9, anticorps wu:fj02h02, anticorps prka9, anticorps yotiao, anticorps akap350, anticorps akap450, anticorps hyperion, anticorps AKAP120, anticorps A-kinase anchoring protein 9, anticorps A kinase (PRKA) anchor protein (yotiao) 9, anticorps A kinase (PRKA) anchor protein 9, anticorps A-kinase anchoring protein AKAP120, anticorps AKAP9, anticorps Akap9, anticorps akap9, anticorps CpipJ_CPIJ006715, anticorps CpipJ_CPIJ017436
    Sujet
    Compartmentalization of the type II cAMP-dependent protein kinase (PKA) within the cell is essential for its discrete physiological effects. PKA localization is mediated by interactions between the regulatory (RII) subunit and A-kinase anchoring proteins (AKAPs) which position PKA in close proximity to relevant substrates. Some AKAPs exhibit tissue specific expression, while others are detected ubiquitously. AKAP450 localizes PKA type II to centrosomes. The N-terminal portion of AKAP450 (amino acids 1-1626) is almost identical to the Yotiao protein (~210 kDa), an AKAP that localizes PKA to NMDA receptors. In addition, AKAP450 contains three major regions (cc1, cc2, cc3) of coiled coil structures, which are characteristic features of centrosomeal proteins. It is expressed at low levels in multiple tissues, including skeletal muscle and liver, but is highly expressed in kidney. PKA is thought to be involved in the maintenance of the interphase microtubule network and to be necessary for stabilization of minus-end microtubules that originate from the centrosome. Thus AKAP450 may serve as a scaffolding protein to localize PKA and other signaling molecules together in cetrosomes. This antibody is routinely tested by western blot analysis.
    Poids moléculaire
    450 kDa
    Pathways
    M Phase, SARS-CoV-2 Protein Interactome
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