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SLC1A2 anticorps (AA 562-574)

SLC1A2 Reactivité: Rat WB Hôte: Souris Monoclonal 20-EAAT2 unconjugated
N° du produit ABIN968626
  • Antigène Voir toutes SLC1A2 Anticorps
    SLC1A2 (Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2))
    Épitope
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 562-574
    Reactivité
    • 49
    • 25
    • 25
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Rat
    Hôte
    • 48
    • 7
    • 1
    Souris
    Clonalité
    • 48
    • 8
    Monoclonal
    Conjugué
    • 36
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SLC1A2 est non-conjugé
    Application
    • 40
    • 24
    • 22
    • 7
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
     Réactivité croisée
    Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human EAAT2 aa. 562-574
    Clone
    20-EAAT2
    Isotype
    IgG1
    Top Product
    Discover our top product SLC1A2 Anticorps primaire
  • Commentaires

    Related Products: ABIN968545, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Grunewald, Kanner: "The accessibility of a novel reentrant loop of the glutamate transporter GLT-1 is restricted by its substrate." dans: The Journal of biological chemistry, Vol. 275, Issue 13, pp. 9684-9, (2000) (PubMed).

    Yamada, Watanabe, Shibata, Nagashima, Tanaka, Inoue: "Glutamate transporter GLT-1 is transiently localized on growing axons of the mouse spinal cord before establishing astrocytic expression." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 18, Issue 15, pp. 5706-13, (1998) (PubMed).

    Tanaka, Watase, Manabe, Yamada, Watanabe, Takahashi, Iwama, Nishikawa, Ichihara, Kikuchi, Okuyama, Kawashima, Hori, Takimoto, Wada: "Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1." dans: Science (New York, N.Y.), Vol. 276, Issue 5319, pp. 1699-702, (1997) (PubMed).

    Kirschner, Copeland, Gilbert, Jenkins, Amara: "Mouse excitatory amino acid transporter EAAT2: isolation, characterization, and proximity to neuroexcitability loci on mouse chromosome 2." dans: Genomics, Vol. 24, Issue 2, pp. 218-24, (1995) (PubMed).

  • Antigène
    SLC1A2 (Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2))
    Autre désignation
    EAAT2 (SLC1A2 Produits)
    Synonymes
    anticorps CG3159, anticorps Dmel\\CG3159, anticorps EAAT, anticorps dEAAT2, anticorps dEaat2, anticorps Eaat, anticorps GB16377, anticorps EAAT2, anticorps SLC1A2, anticorps Eaat2, anticorps Glt, anticorps Glt-1, anticorps GLT-1, anticorps 1700091C19Rik, anticorps 2900019G14Rik, anticorps AI159670, anticorps GLT1, anticorps MGLT1, anticorps eaat2, anticorps fj34b12, anticorps slc1a2, anticorps wu:fj34b12, anticorps zgc:65897, anticorps Excitatory amino acid transporter 2, anticorps excitatory amino acid transporter 2, anticorps solute carrier family 1 member 2, anticorps solute carrier family 1 (glial high affinity glutamate transporter), member 2, anticorps solute carrier family 1 (glial high affinity glutamate transporter), member 2b, anticorps Eaat2, anticorps Eaat-2, anticorps SLC1A2, anticorps VDBG_06180, anticorps EUBELI_01747, anticorps Trebr_0139, anticorps Slc1a2, anticorps slc1a2b
    Sujet
    Electrogenic-coupled (Na+ and K+) glutamate transporters in nerve terminals and glial cells are essential for maintaining subtoxic levels of extracellular excitatory amino acid neurotransmitters (e.g. glutamate and aspartate). They are also important for modifying synaptic transmission through the cotransport of ions and neurotransmitters. Excitatory amino acid transporter 2 (EAAT2) has 8 alpha-helical transmembrane domains and two reentrant pore-loop-like structures whose conformation is altered during ion neurotransmitter transport. EAAT2 is primarily expressed in astrocytes in adult brain and spinal cord, however it is also found in axons during fetal development. Mice deficient in EAAT2 exhibit lethal epileptic seizures with destruction of hippocampal neurons and an increased susceptibility to cold-induced cortical injury. Such defects in glutamine transporters have also been implicated in stroke, brain trauma, Alzheimer's disease, amyotrophic lateral sclerosis, and Huntington's disease. Thus, glutamine transporters, such as EAAT2, are critical for prevention of neurotoxic brain injury and may regulate glutamatergic synaptic transmission. This antibody is routinely tested by western blot analysis.
    Synonyms: Excitatory amino acid transporter 2, Glutamate transporter 1, GLT1
    Poids moléculaire
    66 kDa
    Pathways
    Dicarboxylic Acid Transport
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