Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

Doublecortin anticorps (AA 211-317)

DCX Reactivité: Souris WB, IF Hôte: Souris Monoclonal 30-Doublecortin unconjugated
N° du produit ABIN968637
  • Antigène Voir toutes Doublecortin (DCX) Anticorps
    Doublecortin (DCX)
    Épitope
    • 7
    • 7
    • 7
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 211-317
    Reactivité
    • 111
    • 72
    • 67
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Souris
    Hôte
    • 102
    • 11
    • 2
    • 2
    Souris
    Clonalité
    • 97
    • 20
    Monoclonal
    Conjugué
    • 64
    • 9
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Doublecortin est non-conjugé
    Application
    • 74
    • 41
    • 33
    • 12
    • 12
    • 11
    • 9
    • 8
    • 8
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Mouse Doublecortin aa. 211-317
    Clone
    30-Doublecortin
    Isotype
    IgG1
    Top Product
    Discover our top product DCX Anticorps primaire
  • Commentaires

    Related Products: ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Magavi, Leavitt, Macklis: "Induction of neurogenesis in the neocortex of adult mice." dans: Nature, Vol. 405, Issue 6789, pp. 951-5, (2000) (PubMed).

    des Portes, Pinard, Billuart, Vinet, Koulakoff, Carrié, Gelot, Dupuis, Motte, Berwald-Netter, Catala, Kahn, Beldjord, Chelly: "A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome." dans: Cell, Vol. 92, Issue 1, pp. 51-61, (1998) (PubMed).

    Gleeson, Allen, Fox, Lamperti, Berkovic, Scheffer, Cooper, Dobyns, Minnerath, Ross, Walsh: "Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein." dans: Cell, Vol. 92, Issue 1, pp. 63-72, (1998) (PubMed).

  • Antigène
    Doublecortin (DCX)
    Autre désignation
    Doublecortin (DCX Produits)
    Synonymes
    anticorps DCX, anticorps DBCN, anticorps DC, anticorps LISX, anticorps SCLH, anticorps XLIS, anticorps Dbct, anticorps 18C15.5, anticorps doublecortin, anticorps DCX, anticorps Dcx
    Sujet
    The cerebral cortex is composed of multiple layers of neurons of distinct types and functions, which perform in unison to orchestrate cognitive function. The formation of the cortex relies on complex signaling mechanisms, which mediate the migration of newly formed neurons from deep within the brain to the superficial regions. Defects in neuronal migration and disruption of the multi-layered cortex are apparent in conditions such as X-linked lissencephaly (XLIS) and subcortical laminar heterotopia (SCLH) or double cortex (DC) syndrome. Mutations in the doublecortin gene have been linked to these brain disorders. Doublecortin is highly expressed in developing brain, primarily in migrating neurons. It is significantly homologous with the N-terminal region of the product of the KIAA0369 gene, a protein that is also similar to the CaM kinase family in its C-terminal region. Doublecortin has four potential MAP kinase family phosphorylation sites and a putative site for Abl tyrosine phosphorylation. Thus, doublecortin is thought to be an integral component of tyrosine kinase signal transduction pathways that regulate neuronal migration and development of the cerebral cortex.
    Poids moléculaire
    41 kDa
Vous êtes ici:
Support technique