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ILK anticorps (AA 326-452)

ILK Reactivité: Humain, Souris, Rat, Chien, Poulet WB, IF Hôte: Souris Monoclonal 3-ILK unconjugated
N° du produit ABIN968662
  • Antigène Voir toutes ILK Anticorps
    ILK (Integrin-Linked Kinase (ILK))
    Épitope
    • 25
    • 24
    • 16
    • 15
    • 15
    • 9
    • 9
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 326-452
    Reactivité
    • 160
    • 59
    • 52
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Chien, Poulet
    Hôte
    • 169
    • 5
    • 1
    Souris
    Clonalité
    • 167
    • 8
    Monoclonal
    Conjugué
    • 64
    • 16
    • 16
    • 14
    • 10
    • 10
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    Cet anticorp ILK est non-conjugé
    Application
    • 123
    • 97
    • 60
    • 40
    • 39
    • 20
    • 17
    • 9
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Poulet, Chien, Souris, Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human ILK aa. 326-452
    Clone
    3-ILK
    Isotype
    IgG1
    Top Product
    Discover our top product ILK Anticorps primaire
  • Commentaires

    Related Products: ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Nikolopoulos, Turner: "Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localization." dans: The Journal of biological chemistry, Vol. 277, Issue 2, pp. 1568-75, (2002) (PubMed).

    Nikolopoulos, Turner: "Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions." dans: The Journal of biological chemistry, Vol. 276, Issue 26, pp. 23499-505, (2001) (PubMed).

    Persad, Attwell, Gray, Delcommenne, Troussard, Sanghera, Dedhar: "Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 7, pp. 3207-12, (2000) (PubMed).

    Delcommenne, Tan, Gray, Rue, Woodgett, Dedhar: "Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 19, pp. 11211-6, (1998) (PubMed).

    Hannigan, Leung-Hagesteijn, Fitz-Gibbon, Coppolino, Radeva, Filmus, Bell, Dedhar: "Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase." dans: Nature, Vol. 379, Issue 6560, pp. 91-6, (1996) (PubMed).

  • Antigène
    ILK (Integrin-Linked Kinase (ILK))
    Autre désignation
    ILK (ILK Produits)
    Synonymes
    anticorps CG10504, anticorps CT29478, anticorps DmILK, anticorps Dmel\\CG10504, anticorps ILK, anticorps ilk, anticorps l(3)78Ca, anticorps p59, anticorps AA511515, anticorps ESTM24, anticorps zgc:65842, anticorps ILK-1, anticorps ILK-2, anticorps P59, anticorps p59ILK, anticorps Integrin linked kinase, anticorps integrin linked kinase, anticorps integrin linked kinase S homeolog, anticorps integrin-linked protein kinase, anticorps integrin-linked kinase, anticorps Ilk, anticorps ILK, anticorps ilk.S, anticorps CpipJ_CPIJ016644, anticorps Bm1_20815, anticorps Tsp_07213, anticorps Tsp_07224, anticorps Tsp_15354, anticorps ilk
    Sujet
    Integrins are transmembrane receptors that mediate cell-cell or cell-matrix adhesion. All integrins are heterodimers composed of alpha and beta subunits, which interact with extracellular matrix and cytoskeletal proteins. Signal transduction through intergin receptors may be regulated by integrin-linked kinase (ILK). ILK is a widely expressed Ser/Thr protein kinase that contains four ankyrin-like repeats in the N-terminal region, a phoshoinositide lipid-binding motif at amino acids 180-212, and an integrin binding site at amino acids 293-451. The ankyrin repeats interact with a LIM domain-only protein called PINCH that also binds the adaptor protein, Nck-2. This interaction implicates ILK in growth factor receptor pathways. In addition, the interaction of ILK with the cytoplasmic domains of integrin beta1 and beta3 subunits and localization of ILK to focal adhesion plaques suggests a role for ILK in the regulation of cell adhesion. Interestingly, overexpression of ILK in epithelial cells inhibits cell adhesion and stimulates cell cycle progression and tumorigenicity. Thus, ILK regulates signal transduction in many different cell signaling pathways. This antibody is routinely tested by western blot analysis.
    Poids moléculaire
    50 kDa
    Pathways
    Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Maintenance of Protein Location, Skeletal Muscle Fiber Development, Smooth Muscle Cell Migration
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