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XPO1 anticorps (AA 2-122)

XPO1 Reactivité: Humain, Souris, Rat, Chien, Poulet WB, IF Hôte: Souris Monoclonal 17-Exportin unconjugated
N° du produit ABIN968674
  • Antigène Voir toutes XPO1 Anticorps
    XPO1 (Exportin 1 (XPO1))
    Épitope
    • 15
    • 11
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 2-122
    Reactivité
    • 75
    • 36
    • 35
    • 8
    • 7
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Chien, Poulet
    Hôte
    • 70
    • 5
    Souris
    Clonalité
    • 58
    • 17
    Monoclonal
    Conjugué
    • 42
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp XPO1 est non-conjugé
    Application
    • 48
    • 17
    • 16
    • 15
    • 14
    • 14
    • 9
    • 7
    • 7
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Poulet, Chien, Souris, Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human hCRM1 aa. 2-122
    Clone
    17-Exportin
    Isotype
    IgG1
    Top Product
    Discover our top product XPO1 Anticorps primaire
  • Commentaires

    Related Products: ABIN968553, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Kamura, Hara, Matsumoto, Ishida, Okumura, Hatakeyama, Yoshida, Nakayama, Nakayama: "Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase." dans: Nature cell biology, Vol. 6, Issue 12, pp. 1229-35, (2004) (PubMed).

    Ishida, Hara, Kamura, Yoshida, Nakayama, Nakayama: "Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export." dans: The Journal of biological chemistry, Vol. 277, Issue 17, pp. 14355-8, (2002) (PubMed).

    Massenet, Pellizzoni, Paushkin, Mattaj, Dreyfuss: "The SMN complex is associated with snRNPs throughout their cytoplasmic assembly pathway." dans: Molecular and cellular biology, Vol. 22, Issue 18, pp. 6533-41, (2002) (PubMed).

    Paraskeva, Izaurralde, Bischoff, Huber, Kutay, Hartmann, Lührmann, Görlich: "CRM1-mediated recycling of snurportin 1 to the cytoplasm." dans: The Journal of cell biology, Vol. 145, Issue 2, pp. 255-64, (1999) (PubMed).

    Boer, Bonten-Surtel, Grosveld: "Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis." dans: Molecular and cellular biology, Vol. 18, Issue 3, pp. 1236-47, (1998) (PubMed).

    Fornerod, Ohno, Yoshida, Mattaj: "CRM1 is an export receptor for leucine-rich nuclear export signals." dans: Cell, Vol. 90, Issue 6, pp. 1051-60, (1997) (PubMed).

  • Antigène
    XPO1 (Exportin 1 (XPO1))
    Autre désignation
    Exportin-1 (XPO1 Produits)
    Synonymes
    anticorps CG13387, anticorps CRM1, anticorps Crm1, anticorps DCRM1, anticorps Dmel\\CG13387, anticorps Emb, anticorps XPO-1, anticorps XPO1, anticorps Xpo1, anticorps crm1, anticorps dCRM1, anticorps l(2)k16715, anticorps 18.m06600, anticorps DDBDRAFT_0183812, anticorps DDBDRAFT_0234066, anticorps DDB_0183812, anticorps DDB_0234066, anticorps exportin-1, anticorps LOC100220104, anticorps emb, anticorps exp1, anticorps Xpo, anticorps AA420417, anticorps Exp1, anticorps embargoed, anticorps exportin 1, anticorps putative exportin 1, anticorps chromosome region maintenance protein 1, anticorps exportin-1, anticorps exportin 1 (CRM1 homolog, yeast), anticorps exportin 1 S homeolog, anticorps emb, anticorps cgd3_3060, anticorps Tc00.1047053511725.150, anticorps Tb11.01.5940, anticorps BBOV_II007220, anticorps LMJF_32_1100, anticorps xpo1, anticorps Xpo1, anticorps XPO1, anticorps LOC100165622, anticorps LOC100633509, anticorps xpo1.S
    Sujet
    The nuclear pore complex (NPC) is a 125 MDa nuclear envelope complex that mediates nucleocytoplasmic shuttling of RNA and protein. NPC is comprised of more than 30 different proteins, including Ran/TC4, importins, and exportins . Exportin-1(hCRM1/XPO1) is the widely expressed human homologue of the yeast CRM1 protein, which functions in the maintenance of chromatin structure and nuclear export. Exportin-1 has an N-terminal CRIME domain that is homologous to yeast CRM1 and importin-beta. Intracellular localization of Exportin-1 shows association with the NPC and overexpression of Exportin-1 in Xenopus oocytes stimulates Rev and U snRNA export from the nucleus. Exportin-1 also binds other nuclear transport related proteins, such as RanGTP, snurportin-1, and the nucleoporins CAN/Nup214 and Nup50. Overexpression of CAN leads to sequestration of Exportin-1 in the nucleoplasm, which inhibits cell growth and induces apoptosis. In addition, Exportin-1 may export specific proteins, such as Rev and PKI, via binding to a leucine-rich nuclear export signal (NES). Thus, Exportin-1 is an important protein and RNA nuclear export receptor, which may be required for normal cell growth and survival. This antibody is routinely tested by western blot analysis.
    Synonyms: CRM1
    Poids moléculaire
    112 kDa
    Pathways
    M Phase
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