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Cullin 3 anticorps (AA 565-684)

CUL3 Reactivité: Humain, Souris, Rat, Poulet, Chien WB, IF Hôte: Souris Monoclonal 3-CUL unconjugated
N° du produit ABIN968679
  • Antigène Voir toutes Cullin 3 (CUL3) Anticorps
    Cullin 3 (CUL3)
    Épitope
    • 15
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 565-684
    Reactivité
    • 53
    • 22
    • 18
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Humain, Souris, Rat, Poulet, Chien
    Hôte
    • 51
    • 1
    • 1
    Souris
    Clonalité
    • 48
    • 5
    Monoclonal
    Conjugué
    • 32
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Cullin 3 est non-conjugé
    Application
    • 25
    • 16
    • 13
    • 13
    • 13
    • 6
    • 6
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Souris, Rat (Rattus), Chien, Poulet
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human CUL-3 aa. 565-684
    Clone
    3-CUL
    Isotype
    IgG1
    Top Product
    Discover our top product CUL3 Anticorps primaire
  • Commentaires

    Related Products: ABIN968545, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Hori, Osaka, Chiba, Miyamoto, Okabayashi, Shimbara, Kato, Tanaka: "Covalent modification of all members of human cullin family proteins by NEDD8." dans: Oncogene, Vol. 18, Issue 48, pp. 6829-34, (2000) (PubMed).

    Singer, Gurian-West, Clurman, Roberts: "Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells." dans: Genes & development, Vol. 13, Issue 18, pp. 2375-87, (1999) (PubMed).

  • Antigène
    Cullin 3 (CUL3)
    Autre désignation
    CUL-3 (CUL3 Produits)
    Synonymes
    anticorps CUL-3, anticorps Cullin-3, anticorps CUL-3-A, anticorps Cullin-3-A, anticorps cul3, anticorps cul3a, anticorps CUL-3-B, anticorps Cullin-3-B, anticorps cul3b, anticorps wu:fc37e01, anticorps CUL3, anticorps ATCUL3, anticorps ATCUL3A, anticorps CUL3A, anticorps T24P13.25, anticorps cullin 3, anticorps cullin 3A, anticorps PHA2E, anticorps AI467304, anticorps AW146203, anticorps mKIAA0617, anticorps cullin 3, anticorps cullin 3 L homeolog, anticorps cullin 3 S homeolog, anticorps cullin-3, anticorps Cullin-3 (CUL-3), anticorps cullin 3a, anticorps CULlin, anticorps CUL3, anticorps cul3, anticorps cul3.L, anticorps cul3.S, anticorps PTRG_11586, anticorps Smp_117580, anticorps cul3a, anticorps Cul3, anticorps cul-3
    Sujet
    The cullins are a family of proteins that are integral to cell cycle regulation. Members of this family include human Cul proteins, C.elegans Ce-Cul-1, and S. cerevisiae Cdc53. Proper control of cell cycle progression is essential for the prevention of tumorigenesis. Mutant forms of both Ce-Cul-1 and Cdc53 have been implicated in the oncogenic process. The human Cul family of proteins, Cul-1, -2, -3, -4A, -4B, and -5, have also been implicated in oncogenic processes. Abnormal nuclear localization of Cul-2 is seen in a rare hereditary condition known as VHL (von Hippel-Lindau) syndrome. Patients with VHL syndrome possess a mutant VHL gene and develop cancers such as retinal anginomas, CNS hemangioblastomas, and renal cell carcinomas. Cul-3 is widely expressed in normal cells and tissues, and shows increased expression in colon cancer cells. Cul-3 can associate with cyclin E in mammalian cells, and overexpression of Cul-3 targets cyclin E for ubiquination, while deletion of Cul-3 in mice leads to increased cyclin E accumulation and abnormal regulation of S-phase. Thus, the Cul family of proteins may have roles in cell cycle regulation and tumoriogenesis. This antibody is routinely tested by western blot analysis.
    Poids moléculaire
    89 kDa
    Pathways
    M Phase
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