Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

AP4E1 anticorps (AA 685-793)

AP4E1 Reactivité: Humain WB, IF Hôte: Souris Monoclonal 32-Adaptin epsilon unconjugated
N° du produit ABIN968712
  • Antigène Voir toutes AP4E1 Anticorps
    AP4E1 (Adaptor-Related Protein Complex 4, epsilon 1 Subunit (AP4E1))
    Épitope
    • 1
    • 1
    AA 685-793
    Reactivité
    Humain
    Hôte
    • 1
    • 1
    Souris
    Clonalité
    • 2
    Monoclonal
    Conjugué
    • 2
    Cet anticorp AP4E1 est non-conjugé
    Application
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human Adaptin epsilon aa. 685-793
    Clone
    32-Adaptin epsilon
    Isotype
    IgG1
    Top Product
    Discover our top product AP4E1 Anticorps primaire
  • Commentaires

    Related Products: ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Aguilar, Boehm, Gorshkova, Crouch, Tomita, Saito, Ohno, Bonifacino: "Signal-binding specificity of the mu4 subunit of the adaptor protein complex AP-4." dans: The Journal of biological chemistry, Vol. 276, Issue 16, pp. 13145-52, (2001) (PubMed).

    DellAngelica, Mullins, Bonifacino: "AP-4, a novel protein complex related to clathrin adaptors." dans: The Journal of biological chemistry, Vol. 274, Issue 11, pp. 7278-85, (1999) (PubMed).

    Hirst, Bright, Rous, Robinson: "Characterization of a fourth adaptor-related protein complex." dans: Molecular biology of the cell, Vol. 10, Issue 8, pp. 2787-802, (1999) (PubMed).

  • Antigène
    AP4E1 (Adaptor-Related Protein Complex 4, epsilon 1 Subunit (AP4E1))
    Autre désignation
    Adaptin epsilon (AP4E1 Produits)
    Synonymes
    anticorps CPSQ4, anticorps SPG51, anticorps RGD1562199, anticorps 2310033A20Rik, anticorps 9930028M04Rik, anticorps AV087807, anticorps adaptor related protein complex 4 epsilon 1 subunit, anticorps adaptor-related protein complex 4, epsilon 1 subunit, anticorps adaptor-related protein complex AP-4, epsilon 1, anticorps AP4E1, anticorps Ap4e1
    Sujet
    Sorting of integral membrane proteins is mediated by vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1, AP-2, AP-3, and AP-4), which are associated with the vesicle coats. These coatomers contain two large adaptin proteins (gamma, alpha, sigma, epsilon and beta1, beta2, beta3, beta4 respectively) that are noncovalently linked to one medium chain (µ1, µ2, µ3, µ4 respectively) and one small chain (sigma1, sigma2, sigma3, sigma4 respectively). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2 adaptor complexes are involved in clathrin-mediated endocytosis. AP-4 is associated with non-clathrin coated vesicles in the region of the TGN. This localization is disrupted by brefeldin A, indicating that AP-4 membrane attachment is regulated by small GTPases. The µ4 subunit of the AP-4 complex interacts with tyrosine-based signals on LAMP-2 during targeting to the endosomal-lysosomal system. Thus, AP-4 is a less abundant AP complex that may be important for vesicle trafficking from the Golgi to the endosomal-lysosomal system.
    Poids moléculaire
    127 kDa
Vous êtes ici:
Support technique