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TAF4 anticorps (AA 454-565)

TAF4 Reactivité: Humain, Souris WB, IF Hôte: Souris Monoclonal 22-TAF[II]135 unconjugated
N° du produit ABIN968728
  • Antigène Voir toutes TAF4 Anticorps
    TAF4 (TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa (TAF4))
    Épitope
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 454-565
    Reactivité
    • 19
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 17
    • 4
    Souris
    Clonalité
    • 18
    • 3
    Monoclonal
    Conjugué
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TAF4 est non-conjugé
    Application
    • 13
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Souris
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human TAF[II]135 aa. 454-565
    Clone
    22-TAF[II]135
    Isotype
    IgG1
    Top Product
    Discover our top product TAF4 Anticorps primaire
  • Commentaires

    Related Products: ABIN968537, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Freiman, Albright, Chu, Zheng, Liang, Sha, Tjian: "Redundant role of tissue-selective TAF(II)105 in B lymphocytes." dans: Molecular and cellular biology, Vol. 22, Issue 18, pp. 6564-72, (2002) (PubMed).

    Shimohata, Nakajima, Yamada, Uchida, Onodera, Naruse, Kimura, Koide, Nozaki, Sano, Ishiguro, Sakoe, Ooshima, Sato, Ikeuchi, Oyake, Sato, Aoyagi, Hozumi, Nagatsu, Takiyama, Nishizawa, Goto, Kanazawa et al.: "Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription. ..." dans: Nature genetics, Vol. 26, Issue 1, pp. 29-36, (2000) (PubMed).

    Saluja, Vassallo, Tanese: "Distinct subdomains of human TAFII130 are required for interactions with glutamine-rich transcriptional activators." dans: Molecular and cellular biology, Vol. 18, Issue 10, pp. 5734-43, (1998) (PubMed).

    Mengus, May, Carré, Chambon, Davidson: "Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells." dans: Genes & development, Vol. 11, Issue 11, pp. 1381-95, (1997) (PubMed).

  • Antigène
    TAF4 (TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa (TAF4))
    Autre désignation
    TAF II135 (TAF4 Produits)
    Synonymes
    anticorps CG5444, anticorps Dmel\\CG5444, anticorps SR3-3, anticorps SY3-2 TAF110, anticorps TAF, anticorps TAF110, anticorps TAF4, anticorps TAFII110, anticorps TAF[II]110, anticorps TAF[[II]], anticorps TAF[[II]]110, anticorps TFIID, anticorps TFIID 110, anticorps Taf110, anticorps Taf[[II]]110, anticorps d110, anticorps dTAF4, anticorps dTAFII110, anticorps dTAF[[II]]110, anticorps dmTAF4, anticorps l(3)72Dj, anticorps p110, anticorps taf110, anticorps TAF2C, anticorps TAF2C1, anticorps TAF4A, anticorps TAFII130, anticorps TAFII135, anticorps TBP-associated factor 4, anticorps Taf4p, anticorps TATA-box binding protein associated factor 4, anticorps TATA-box binding protein associated factor 4 L homeolog, anticorps Taf4, anticorps TAF4, anticorps taf4.L
    Sujet
    Tightly associated factors (TAFs) play an essential role in transcriptional activation through their interaction with a variety of activators. TAF[II]135 (a.k.a. TAF[II]130) is a human homologue of Drosophila TAF[II]110, the first TAF shown to have coactivator activity. TAF[II]135 contains multiple glutamine-rich regions, as well as a coactivator domain (CAD). The glutamine-rich regions of TAF[II]135 facilitate interaction with Sp1 and CREB, which leads to enhancement of both Sp1- and CREB-mediated transcription. In addition, TAF[II]135 can potentiate transcriptional stimulation by AF-2 of the retinoic acid, thyroid hormone, and vitamine D3 receptors. However, TAF[II]135 does not interact with the AF-2s of the estrogen and retinoid X receptors. Interestingly, TAF[II]135 enhancement of CREB transcriptional activity may be disrupted by expanded polyglutamine (CAG) repeats found in at least eight different neurodegenerative disorders. Thus, TAF[II]135 may have important coactivator activities in many different transcription-regulating cell signaling pathways, and interference of TAF[II]135 activity by CAG repeats may be a common mechanism of specific types of neuropathologies.
    Poids moléculaire
    135 kDa
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