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STAT1 anticorps (pTyr701)

STAT1 Reactivité: Humain, Souris WB, IP, IF, ICS Hôte: Souris Monoclonal 14-P unconjugated
N° du produit ABIN968750
  • Antigène Voir toutes STAT1 Anticorps
    STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))
    Épitope
    • 54
    • 46
    • 16
    • 15
    • 13
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
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    • 1
    • 1
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    • 1
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    • 1
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    • 1
    • 1
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    pTyr701
    Reactivité
    • 208
    • 120
    • 83
    • 24
    • 18
    • 16
    • 15
    • 13
    • 11
    • 10
    • 7
    • 7
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    Humain, Souris
    Hôte
    • 188
    • 38
    • 2
    Souris
    Clonalité
    • 165
    • 63
    Monoclonal
    Conjugué
    • 125
    • 11
    • 11
    • 9
    • 8
    • 8
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Cet anticorp STAT1 est non-conjugé
    Application
    • 149
    • 67
    • 54
    • 54
    • 39
    • 32
    • 26
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    • 26
    • 11
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    • 2
    • 2
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Intracellular Staining (ICS)
     Réactivité croisée
    Souris
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Phosphorylated Human Stat1 (pY701) Peptide
    Clone
    14-P
    Isotype
    IgG1
    Top Product
    Discover our top product STAT1 Anticorps primaire
  • Commentaires

    Related Products: ABIN968533, ABIN968534, ABIN967389, ABIN967758, ABIN967804

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Fu, Zhang: "Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter." dans: Cell, Vol. 74, Issue 6, pp. 1135-45, (1993) (PubMed).

  • Antigène
    STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))
    Autre désignation
    Stat1 (STAT1 Produits)
    Synonymes
    anticorps CANDF7, anticorps ISGF-3, anticorps STAT91, anticorps 2010005J02Rik, anticorps AA408197, anticorps XStat1, anticorps STAT4, anticorps DD6G4-4, anticorps STAT, anticorps STAT1, anticorps dZ182H3.3, anticorps si:by134g18.2, anticorps si:by51f19.1, anticorps si:dz182h3.3, anticorps si:dz199m19.1, anticorps si:dz73o4.2, anticorps stat1, anticorps signal transducer and activator of transcription 1, anticorps signal transducer and activator of transcription 1 L homeolog, anticorps signal transducer and activator of transcription 1, 91kDa, anticorps signal transducer and activator of transcription 4, anticorps signal transducer and activator of transcription 1a, anticorps STAT1, anticorps Stat1, anticorps stat1.L, anticorps stat4, anticorps stat1a
    Sujet
    Stat (Signal transducer and activators of transcription) proteins are critical mediators of the biologic activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of Stat proteins by tyrosine phosphorylation. Active Stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes. Seven Stat proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat1 and Stat2 are components of the ISGF3 (Interferon-Stimulated Gene Factor 3) complex, which is the primary transcription activator induced by the binding of the interferon to a specific cell-surface receptor. Stat1 has two alternatively spliced isoforms, 91-kDa Stat1alpha and 84-kDa Stat1beta, Stat1alpha has 38 additional C-terminal amino acids. In response to the binding of IFNalpha, IFNgamma, EGF, PDGF, or CSF-1 to their respective receptors, the Stat1 subunits become tyrosine-phosphorylated at Y701, and the complex is translocated to the nucleus. This results in the formation of an active complex that includes the DNA-binding p48 subunit. This complex is responsible for modulating the transcription of the interferon-stimulated genes (ISGs).
    The 14/P-STAT1monoclonal antibody recognizes the phosphorylated Y701 in Stat1alpha and Stat1beta.
    Poids moléculaire
    91/84 kDa
    Pathways
    Signalistation JAK/STAT, Signalisation RTK, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events
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