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VCP anticorps (AA 9-130)

VCP Reactivité: Humain, Souris, Rat, Chien, Poulet WB, IF Hôte: Souris Monoclonal 18-VCP unconjugated
N° du produit ABIN968778
  • Antigène Voir toutes VCP Anticorps
    VCP (Valosin Containing Protein (VCP))
    Épitope
    • 17
    • 10
    • 9
    • 8
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 9-130
    Reactivité
    • 97
    • 48
    • 40
    • 15
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Chien, Poulet
    Hôte
    • 81
    • 18
    • 2
    Souris
    Clonalité
    • 72
    • 29
    Monoclonal
    Conjugué
    • 60
    • 8
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    Cet anticorp VCP est non-conjugé
    Application
    • 68
    • 39
    • 26
    • 21
    • 20
    • 14
    • 14
    • 13
    • 8
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Humain, Rat (Rattus), Chien, Poulet
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Mouse VCP aa. 9-130
    Clone
    18-VCP
    Isotype
    IgG1
    Top Product
    Discover our top product VCP Anticorps primaire
  • Commentaires

    Related Products: ABIN968540, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Zhang, Wang, Kajino, Greene: "VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells." dans: DNA and cell biology, Vol. 19, Issue 5, pp. 253-63, (2000) (PubMed).

    Zhang, Liu, Kobayashi, Tonks: "Identification of the cell cycle regulator VCP (p97/CDC48) as a substrate of the band 4.1-related protein-tyrosine phosphatase PTPH1." dans: The Journal of biological chemistry, Vol. 274, Issue 25, pp. 17806-12, (1999) (PubMed).

    Zhang, Ashendel, Becker, Morré: "Isolation and characterization of the principal ATPase associated with transitional endoplasmic reticulum of rat liver." dans: The Journal of cell biology, Vol. 127, Issue 6 Pt 2, pp. 1871-83, (1995) (PubMed).

    Egerton, Ashe, Chen, Druker, Burgess, Samelson: "VCP, the mammalian homolog of cdc48, is tyrosine phosphorylated in response to T cell antigen receptor activation." dans: The EMBO journal, Vol. 11, Issue 10, pp. 3533-40, (1992) (PubMed).

  • Antigène
    VCP (Valosin Containing Protein (VCP))
    Autre désignation
    VCP (VCP Produits)
    Synonymes
    anticorps ALS14, anticorps IBMPFD, anticorps TERA, anticorps p97, anticorps CDC48, anticorps wu:fd16d05, anticorps wu:fj63d11, anticorps p93, anticorps 3110001E05, anticorps p97/VCP, anticorps 22.26, anticorps 7.12, anticorps Apple, anticorps BcDNA.GM02885, anticorps BcDNA:GM02885, anticorps CG2331, anticorps DmTER94, anticorps Dmel\CG2331, anticorps I, anticorps Ter94, anticorps Tera, anticorps VCP, anticorps VCP ATPase, anticorps VCP/p97, anticorps Vcp, anticorps anon-WO2004063362.65, anticorps anon-WO2004063362.67, anticorps cdc48, anticorps dTERA, anticorps dVCP, anticorps dmTERA, anticorps dvcp, anticorps l(2)03775, anticorps l(2)46CFf, anticorps l(2)46CFs, anticorps l(2)46Ch, anticorps pTER94, anticorps ter94, anticorps vcp, anticorps FANCG, anticorps valosin containing protein, anticorps valosin containing protein S homeolog, anticorps valosin-containing protein, anticorps CG2331 gene product from transcript CG2331-RA, anticorps zgc:136908, anticorps transitional endoplasmic reticulum ATPase, anticorps VCP, anticorps vcp.S, anticorps vcp, anticorps Vcp, anticorps Bm1_56585, anticorps LOC100136246, anticorps TER94, anticorps zgc:136908, anticorps LOC101109680
    Sujet
    ATPases that belong to the ATPase associated with different cellular activities (AAA) family are homo-oligomeric proteins that have roles in cell cycle regulation, protein degradation, organelle biogenesis, and vesicle mediated-protein transport. Valosin containing protein (VCP) is a AAA family member that is found as a hexamer in rat liver. In vitro, VCP catalyzes the hydrolysis of ATP, but this activity is distinct from classical transport ATPases. VCP protein is found primarily in the transitional elements between the rough and smooth ER (TER), but stimulation with EGF leads to VCP translocation to the nucleus. Antibodies to VCP can perturb cell-free formation of transition vesicles from isolated TER of rat liver, and can inhibit transfer of material from ER to Golgi in a reconstituted membrane system. VCP is phosphorylated after T-cell activation, and PTPH1 dephosphorylation of VCP correlates with suppression of cell growth. In addition, the N-terminal region of VCP binds to the DNA damage repair protein, BRCA1. Thus, VCP may have roles in both ER protein transport and nuclear function, which are important for cell growth and survival. This antibody is routinely tested by western blot analysis.
    Synonyms: Valosin Containing Protein
    Poids moléculaire
    97 kDa
    Pathways
    ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Ubiquitin Proteasome Pathway
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