TNIK anticorps (AA 522-644)

N° du produit ABIN968788

Détail du produit anti-TNIK anticorps

Antigène: TNIK (TRAF2 and NCK Interacting Kinase (TNIK))

Épitope: AA 522-644

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TNIK est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Réactivité croisée: Rat (Rattus), Souris

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human TNIK aa. 522-644

Clone: 53-TNIK

Isotype: IgG1

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-TNIK (ABIN968788)

Fu, Shen, Huang, Lasaga, Payan, Luo: "TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton." dans: The Journal of biological chemistry, Vol. 274, Issue 43, pp. 30729-37, (1999) (PubMed).

Détails sur TNIK

Antigène: TNIK (TRAF2 and NCK Interacting Kinase (TNIK))

Autre désignation: TNIK (TNIK Produits)

Synonymes: anticorps RGD1561817, anticorps TNIK, anticorps 1500031A17Rik, anticorps 4831440I19Rik, anticorps AI451411, anticorps C530008O15Rik, anticorps C630040K21Rik, anticorps fc52d11, anticorps msn, anticorps tnikl, anticorps wu:fc52d11, anticorps zgc:63535, anticorps im:6898857, anticorps zgc:123033, anticorps zgc:152783, anticorps tnik, anticorps TRAF2 and NCK interacting kinase, anticorps TRAF2 and NCK interacting kinase a, anticorps TRAF2 and NCK interacting kinase b, anticorps TRAF2 and NCK interacting kinase S homeolog, anticorps TNIK, anticorps Tnik, anticorps tnika, anticorps tnikb, anticorps tnik.S

Sujet: Ste20 is a S. cerevisiae Ser/Thr protein kinase that functions upstream of the MAP kinase module. Mammalian and yeast homologs of this kinase are divided into two classes based on their structure and regulation. Members of the first class (Ste20, Cla4, and p21-activated protein kinase) contain a C-terminal kinase domain, an N-terminal regulatory domain and a small GTPase Rac1/Cdc42 binding domain. Members of the second class lack the GTPase binding sites, but are similar to the former class throughout the catalytic domain. This second class includes germinal center kinase (GCK), HPK, KHS, KRS1 and 2, MST1, 2, and 3, NIK, SOK-1, and TNIK. Traf2- and NCK-interacting kinase (TNIK) is most homologous to another NCK-interacting kinase, NIK. TNIK contains an N- terminal kinase domain, and a C-terminal GCK homology (GCKH) domain. The mRNA of TNIK is expressed highest in heart, brain, and skeletal muscle. Overexpression of TNIK activates the JNK pathway, and leads to the disruption of F-actin structures and the inhibition of cell spreading. In vitro, TNIK can phosphorylate gelsolin. Thus, TNIK is a GCK family kinase that may regulate both the JNK pathway and cytoskeletal dynamics.

Poids moléculaire: 150 kDa