NMDAR2A anticorps (AA 1093-1214)

N° du produit ABIN968802

Détail du produit anti-NMDAR2A anticorps

Antigène: NMDAR2A (GRIN2A) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A))

Épitope: AA 1093-1214

Reactivité: Rat, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NMDAR2A est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Réactivité croisée: Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Mouse NMDAR2A aa. 1093-1214

Clone: 5-NMDAR2A

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968540, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-NMDAR2A (ABIN968802)

Morikawa, Mori, Kiyama, Mishina, Asano, Kirino: "Attenuation of focal ischemic brain injury in mice deficient in the epsilon1 (NR2A) subunit of NMDA receptor." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 18, Issue 23, pp. 9727-32, (1998) (PubMed).

Ishii, Moriyoshi, Sugihara, Sakurada, Kadotani, Yokoi, Akazawa, Shigemoto, Mizuno, Masu: "Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits." dans: The Journal of biological chemistry, Vol. 268, Issue 4, pp. 2836-43, (1993) (PubMed).

Détails sur NMDAR2A

Antigène: NMDAR2A (GRIN2A) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A))

Autre désignation: NMDAR2A (GRIN2A Produits)

Synonymes: anticorps NMDAR2A, anticorps nr2a, anticorps GRIN2A, anticorps EPND, anticorps GluN2A, anticorps NR2A, anticorps glutamate ionotropic receptor NMDA type subunit 2A, anticorps glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog, anticorps glutamate receptor ionotropic, NMDA 2A, anticorps glutamate receptor, ionotropic, NMDA2A (epsilon 1), anticorps GRIN2A, anticorps grin2a.L, anticorps LOC100438553, anticorps Grin2a

Sujet: The majority of synapses in the central nervous system utilize glutamate as a neurotransmitter to produce rapid neuronal excitation. Glutamate has a diverse array of receptors that can be categorized into two groups, ionotropic and metabotropic. The ionotropic receptors are subdivided into two distinct types: 1) receptors for N-methyl D-aspartate (NMDAR) and 2) non-NMDA receptors for AMPA and kainate. Four types of NMDAR2 have been identified: NMDAR2A (NR2A), NR2B, NR2C, and NR2D. NR2A and NR2B contain a C-terminal extension (> 600 amino acids) that has small, scattered regions of conserved sequence. In embryonic stages, NR2B is expressed throughout the brain, while NR2D is found in diencephalon and brainstem. After birth, NR2A is found throughout the brain, and NR2C is expressed in cerebellum. At this time, NR2B expression becomes restricted to the forebrain, and NR2D expression is strongly reduced. Deletion of the most widespread postnatal NR subunit, NR2A, does not have adverse affects on brain development, but reduces long-term potentiation (LTP) in the hippocampus and impairs spatial and contextual learning. Thus, NR2A may be critical for postnatal learning. This antibody is routinely tested by western blot analysis.
Synonyms: N-Methyl D-Aspartate

Poids moléculaire: 180 kDa

Pathways: Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity