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Nicastrin anticorps (AA 168-289)

NCSTN Reactivité: Humain, Souris, Rat, Poulet, Chien WB, IF Hôte: Souris Monoclonal 35-Nicastrin unconjugated
N° du produit ABIN968805
  • Antigène Voir toutes Nicastrin (NCSTN) Anticorps
    Nicastrin (NCSTN)
    Épitope
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 168-289
    Reactivité
    • 38
    • 33
    • 22
    • 6
    • 6
    • 5
    • 1
    • 1
    Humain, Souris, Rat, Poulet, Chien
    Hôte
    • 52
    • 2
    Souris
    Clonalité
    • 44
    • 10
    Monoclonal
    Conjugué
    • 21
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Nicastrin est non-conjugé
    Application
    • 40
    • 13
    • 13
    • 9
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Poulet, Chien, Souris, Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human Nicastrin aa. 168-289
    Clone
    35-Nicastrin
    Isotype
    IgG2a
    Top Product
    Discover our top product NCSTN Anticorps primaire
  • Commentaires

    Related Products: ABIN967389, ABIN968553

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Chen, Yu, Arawaka, Nishimura, Kawarai, Yu, Tandon, Supala, Song, Rogaeva, Milman, Sato, Yu, Janus, Lee, Song, Zhang, Fraser, St George-Hyslop: "Nicastrin binds to membrane-tethered Notch." dans: Nature cell biology, Vol. 3, Issue 8, pp. 751-4, (2001) (PubMed).

    Yu, Nishimura, Arawaka, Levitan, Zhang, Tandon, Song, Rogaeva, Chen, Kawarai, Supala, Levesque, Yu, Yang, Holmes, Milman, Liang, Zhang, Xu, Sato, Rogaev, Smith, Janus, Zhang, Aebersold, Farrer, Sorbi et al.: "Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. ..." dans: Nature, Vol. 407, Issue 6800, pp. 48-54, (2000) (PubMed).

  • Antigène
    Nicastrin (NCSTN)
    Autre désignation
    Nicastrin (NCSTN Produits)
    Synonymes
    anticorps CG7012, anticorps Dmel\\CG7012, anticorps Nct, anticorps Nic, anticorps S5A, anticorps ST96B, anticorps agro, anticorps dNct, anticorps nic, anticorps NCSTN, anticorps DKFZp469O2418, anticorps APH2, anticorps 9430068N19Rik, anticorps AA727311, anticorps Aph2, anticorps D1Dau13e, anticorps Kiaa0253, anticorps mKIAA0253, anticorps nicastrin, anticorps Nicastrin, anticorps NCSTN, anticorps nct, anticorps ncstn, anticorps CpipJ_CPIJ001617, anticorps Ncstn, anticorps aph-2
    Sujet
    Amyloid precursor protein (APP) gene encodes multiple APPs ranging from 695 to 770 amino acids. The unprocessed form of APP is a putative cell surface receptor that possesses neurite-promoting activity, and is involved in synaptic vesicle recycling. Processing of APP by sequential enzymatic activity of beta- and gamma-secretase, and the presenilin proteins PS1 and PS2, produces APP fragments that may have unique functions. beta-secretase activity cleaves the extracellular portion of APP leading to asecreted APP form, while gamma-secretase activity produces beta-Amyloid peptide (39-43 amino acids). The Abeta peptide produces abnormal plaques in the cerebral cortex and blood vesselwalls during Alzheimer's disease. Nicastrin is a PS1 associated transmembrane protein,that contains N-terminal glycosylation and myristoylation sites. Nicastrin can bind full length APP and the fragments produced by gamma-secretase. In C. elegans, suppression of nicastrin expression produces phenotypes that mimic those produced when notch signaling proteins are suppressed. In Drosophila, deficiencies in nicastrin prevent cleavage of the intracellular portion of Notch. Thus, nicastrin may be a functional component of presenilins and gamma-secretase complexes, which process Notch and APP transmembrane receptors.
    Poids moléculaire
    110 kDa
    Pathways
    Signalisation Notch, Neurotrophin Signaling Pathway
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