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SEC31A anticorps (AA 522-719)

SEC31A Reactivité: Humain WB, IF Hôte: Souris Monoclonal 32-Sec31A unconjugated
N° du produit ABIN968830
  • Antigène Voir toutes SEC31A Anticorps
    SEC31A (SEC31 Homolog A (SEC31A))
    Épitope
    • 8
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 522-719
    Reactivité
    • 31
    • 13
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 23
    • 9
    Souris
    Clonalité
    • 23
    • 9
    Monoclonal
    Conjugué
    • 16
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SEC31A est non-conjugé
    Application
    • 19
    • 12
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human Sec31A aa. 522-719
    Clone
    32-Sec31A
    Isotype
    IgG1
    Top Product
    Discover our top product SEC31A Anticorps primaire
  • Commentaires

    Related Products: ABIN968537, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Tang, Ong, Huang, Wei, Wong, Qi, Horstmann, Hong: "A membrane protein enriched in endoplasmic reticulum exit sites interacts with COPII." dans: The Journal of biological chemistry, Vol. 276, Issue 43, pp. 40008-17, (2001) (PubMed).

    Tang, Zhang, Low, Wong, Horstmann, Hong: "Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport." dans: The Journal of biological chemistry, Vol. 275, Issue 18, pp. 13597-604, (2000) (PubMed).

  • Antigène
    SEC31A (SEC31 Homolog A (SEC31A))
    Autre désignation
    Sec31A (SEC31A Produits)
    Synonymes
    anticorps ABP125, anticorps ABP130, anticorps HSPC334, anticorps SEC31L1, anticorps Sec31l1, anticorps VAP1, anticorps 1810024J13Rik, anticorps AU042160, anticorps HSPC275, anticorps cb354, anticorps sec31p, anticorps zgc:63547, anticorps SEC31 homolog A, COPII coat complex component, anticorps Sec31 homolog A (S. cerevisiae), anticorps SEC31A, anticorps Sec31a, anticorps sec31a
    Sujet
    Eukaryotic protein trafficking involves packaging of target molecules into membranous vesicles that bud from a donor compartment, travel to a specific destination, fuse, and release their contents into an acceptor compartment. Vesicles that bud from the Golgi cisternae and from the ER contain a non-clathrin based coat. This coat is an oligomeric complex whose subunits are termed COPs (coatomer proteins). COPI is the golgi- and endosome-associated COP complex, while COPII is the ER-associated coat complex. In yeast, the COPII complex has a cargo binding subcomplex that includes Sar1p, Sec23p, and Sec24p, which recruits Sec13p and Sec31p leading to vesicle formation. The human homologues of Sec31p are Sec31A and Sec31B. Sec31A has 40% identity with Sec31B, and contains an N-terminal WD-40 domain and a C-terminal proline-rich region. Sec31A mRNA is widely expressed, while Sec31B is found only in testis and thymus. In HeLa, Sec31A localizes to vesicular structures in the perinuclear region of the cell, and co-localizes with the COPII component Sec13. Antibodies against Sec31A inhibit ER to Golgi transport of vesicular stomatitis G protein. Thus, Sec31 may be an important COPII component involved in ER to Golgi transport, as well as a marker for COPII vesicles.
    Poids moléculaire
    148 kDa
    Pathways
    ER-Nucleus Signaling
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