HERC2 anticorps (AA 1781-1974)

N° du produit ABIN968838

Détail du produit anti-HERC2 anticorps

Antigène: HERC2 (Hect Domain and RLD 2 (HERC2))

Épitope: AA 1781-1974

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HERC2 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain, Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Mouse HERC2 aa. 1781-1974

Clone: 17-HERC2

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-HERC2 (ABIN968838)

Ji, Rebert, Joslin, Higgins, Schultz, Nicholls: "Structure of the highly conserved HERC2 gene and of multiple partially duplicated paralogs in human." dans: Genome research, Vol. 10, Issue 3, pp. 319-29, (2000) (PubMed).

Lehman, Nakatsu, Ching, Bronson, Oakey, Keiper-Hrynko, Finger, Durham-Pierre, Horton, Newton, Lyon, Brilliant: "A very large protein with diverse functional motifs is deficient in rjs (runty, jerky, sterile) mice." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 16, pp. 9436-41, (1998) (PubMed).

Détails sur HERC2

Antigène: HERC2 (Hect Domain and RLD 2 (HERC2))

Autre désignation: HERC2 (HERC2 Produits)

Synonymes: anticorps CG11734, anticorps Dmel\\CG11734, anticorps D15F32S1h, anticorps D7H15F32S1, anticorps D7H15F37S1, anticorps jdf2, anticorps mKIAA0393, anticorps rjs, anticorps D15F37S1, anticorps SHEP1, anticorps p528, anticorps HECT and RLD domain containing protein 2, anticorps HECT and RLD domain containing E3 ubiquitin protein ligase 2, anticorps HERC2, anticorps Herc2

Sujet: Prader-Willi and Angelman syndromes are genetic disorders that result from recombination between chromsome-specific low-copy repeats (duplicons). ERC2(rjs) is the transcript found in the duplicon for these disorders, and recessive mutation of HERC2 leads to a developmental syndrome in mice, referred to as runty jerky sterile (rjs) and juvenile development and fertility 2 (jdf2). HERC2 is homologous to the HERC1 and HERC3 HECT-domain containing proteins. The sequence of HERC2 includes three RCC1-like domains (RLD), a C-terminal ECT domain, and a ZZ-type zinc finger. The RCC1 repeats are similar to those found in cytochrome b5 and the HECT domain is found in E6-AP ubiquitin ligase. HERC2 may function as both a guanine nucleotide exchange factor and E3 biquitin ligase based on its conserved motifs and observation from mouse mutation studies. HERC2 mRNA is expressed highest in brain and testes, but is also found in heart, lung, liver, skeletal muscle, and kidney. Thus, HERC2 may function in protein trafficking and degradation pathways in various tissues.

Poids moléculaire: 527 kDa