HNF1B anticorps (AA 1-101)

N° du produit ABIN968855

Détail du produit anti-HNF1B anticorps

Antigène: HNF1B (HNF1 Homeobox B (HNF1B))

Épitope: AA 1-101

Reactivité: Humain, Souris, Rat, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HNF1B est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Réactivité croisée: Rat (Rattus), Humain, Chien

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Mouse HNF-1beta aa. 1-101

Clone: 25-HNF

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968547, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-HNF1B (ABIN968855)

Soubt, Marksitzer, Menoud, Nagamine: "Role of tissue-specific transcription factor LFB3 in a cyclic AMP-responsive enhancer of the urokinase-type plasminogen activator gene in LLC-PK1 cells." dans: Molecular and cellular biology, Vol. 18, Issue 8, pp. 4698-706, (1998) (PubMed).

Ringeisen, Rey-Campos, Yaniv: "The transactivation potential of variant hepatocyte nuclear factor 1 is modified by alternative splicing." dans: The Journal of biological chemistry, Vol. 268, Issue 34, pp. 25706-11, (1994) (PubMed).

De Simone, De Magistris, Lazzaro, Gerstner, Monaci, Nicosia, Cortese: "LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia." dans: The EMBO journal, Vol. 10, Issue 6, pp. 1435-43, (1991) (PubMed).

Détails sur HNF1B

Antigène: HNF1B (HNF1 Homeobox B (HNF1B))

Autre désignation: HNF-1beta (HNF1B Produits)

Synonymes: anticorps FJHN, anticorps HNF-1B, anticorps HNF1beta, anticorps HNF2, anticorps HPC11, anticorps LF-B3, anticorps LFB3, anticorps MODY5, anticorps TCF-2, anticorps TCF2, anticorps VHNF1, anticorps HNF-1b, anticorps HNF1B, anticorps AI385728, anticorps AI987804, anticorps HNF-1Beta, anticorps Hnf1beta, anticorps Tcf-2, anticorps Tcf2, anticorps vHNF1, anticorps vHNF-1, anticorps chunp6877, anticorps hnf1b, anticorps mst, anticorps tcf2, anticorps vhnf1, anticorps lfb3, anticorps hnf-1beta, anticorps hnf1-beta, anticorps hnf1beta, anticorps HNF1g, anticorps wu:fc23f06, anticorps HNF1 homeobox B, anticorps HNF1 homeobox Ba, anticorps HNF1 homeobox B S homeolog, anticorps HNF1 homeobox B L homeolog, anticorps HNF1 homeobox Bb, anticorps HNF1B, anticorps Hnf1b, anticorps hnf1ba, anticorps hnf1b.S, anticorps hnf1b.L, anticorps hnf1bb

Sujet: HNF's (Hepatocyte Nuclear Factor) are POU-homeodomain-containing liver enriched transcription factors that include HNF1-alpha, HNF1-beta, HNF-3alpha, HNF-3beta, HNF-4 and HNF-6. HNF-1 is expressed in liver, kidney, and intestine, while HNF-1beta is expressed highest in kidney with lower levels in intestine, lung, and liver. Both HNF-1 and HNF-1beta have short N-terminal alpha-helical segments that facilitate homodimerization (A-domain), a region related to POU-specific A-box (B-domain), and a homeodomain (C-domain). The HNF-1 and HNF-1beta homo- and hetero-dimers transactivate genes required for development of various tissues. Both transcription factors can bind the consensus HNF1 inverted palindromic sequence GTTAATNATTAAC. HNF-1 represses its own transcription and data suggests that there is coordinate regulation between HNF-1 and HNF-4. Although HNF-4 induces HNF-1 transcription, HNF-1 downregulates HNF-4 activity by binding to the AF2 region in the activation domain of HNF-4. Thus, HNF transcription factors may be involved in various aspects of the regulation of gene transcription throughout development.
Synonyms: Hepatocyte Nuclear Factor-1beta

Poids moléculaire: 51 kDa

Pathways: Hormone Transport, Stem Cell Maintenance, Tube Formation