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CTNND1 anticorps (pTyr228)

CTNND1 Reactivité: Humain, Souris, Rat WB, IF, FACS Hôte: Souris Monoclonal 21a-p120 Catenin unconjugated
N° du produit ABIN968863
  • Antigène Voir toutes CTNND1 Anticorps
    CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))
    Épitope
    • 22
    • 20
    • 17
    • 16
    • 15
    • 7
    • 7
    • 7
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr228
    Reactivité
    • 142
    • 123
    • 51
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 149
    • 24
    Souris
    Clonalité
    • 143
    • 30
    Monoclonal
    Conjugué
    • 65
    • 12
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CTNND1 est non-conjugé
    Application
    • 113
    • 54
    • 54
    • 43
    • 35
    • 29
    • 28
    • 25
    • 16
    • 15
    • 14
    • 4
    • 4
    • 3
    • 2
    Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)
     Réactivité croisée
    Humain, Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Mouse p120 Catenin (pY228)
    Clone
    21a-p120 Catenin
    Isotype
    IgG1
    Top Product
    Discover our top product CTNND1 Anticorps primaire
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Mariner, Anastasiadis, Keilhack, Böhmer, Wang, Reynolds: "Identification of Src phosphorylation sites in the catenin p120ctn." dans: The Journal of biological chemistry, Vol. 276, Issue 30, pp. 28006-13, (2001) (PubMed).

  • Antigène
    CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))
    Autre désignation
    p120 Catenin (CTNND1 Produits)
    Synonymes
    anticorps CAS, anticorps CTNND, anticorps P120CAS, anticorps P120CTN, anticorps p120, anticorps p120(CAS), anticorps p120(CTN), anticorps Catns, anticorps cas, anticorps Xp120, anticorps ctnnd, anticorps p120cas, anticorps p120ctn, anticorps p120(ctn), anticorps Xp120(ctn), anticorps p120-catenin, anticorps CTNND1, anticorps AA409437, anticorps AU019353, anticorps Ctnnd, anticorps P120, anticorps mKIAA0384, anticorps catenin delta 1, anticorps catenin (cadherin-associated protein), delta 1, anticorps catenin (cadherin associated protein), delta 1, anticorps catenin delta 1 L homeolog, anticorps CTNND1, anticorps Ctnnd1, anticorps ctnnd1, anticorps ctnnd1.L
    Sujet
    The membrane associated protein pp120 Src substrate (p120 Catenin, p120cas)was identified as a tyrosine kinase substrate that is phosphorylated in Src transformed cells or in response to growth factor stimulation. It shares structural similarity with the Drosophila Armadillo protein and the vertebrate beta-catenin and gamma-catenin proteins. This similarity is evidenced by its characteristic Arm domain that is composed of 42-amino acid motif repeats. In the cell, p120 Catenin is localized to the E-Cadherin/catenins cell adhesion complex. Like beta- and gamma-catenin, p120 Catenin directly associates with the cytoplasmic C-terminus of E-Cadherin via its Arm domain and may similarly interact with other Cadherins. It exists as four isoforms that range in size from 90-115kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered pp120 expression contributes to malignancy due to loss of functional cell adhesions. Multiple tyrosine residues (Y96, Y112, Y228, Y280, Y257, Y291, Y296, and Y302) in p120 Catenin are phosphorylated by Src and these phosphorylations may facilitate interaction with PTP1C/SHP-1 in response to EGF stimulation. Thus, p120 Catenin is an Arm domain protein that interacts with both cell adhesion molecules, such as cadherins and cell signaling molecules, such as PTP1C.
    Poids moléculaire
    120 kDa
    Pathways
    EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling
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