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JNK anticorps (pThr183)

MAPK8 Reactivité: Humain, Souris, Rat WB, FACS Hôte: Souris Monoclonal 41-JNK-SAPK unconjugated
N° du produit ABIN968866
  • Antigène Voir toutes JNK (MAPK8) Anticorps
    JNK (MAPK8) (Mitogen-Activated Protein Kinase 8 (MAPK8))
    Épitope
    • 60
    • 28
    • 17
    • 16
    • 16
    • 10
    • 9
    • 9
    • 8
    • 8
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr183
    Reactivité
    • 213
    • 117
    • 100
    • 43
    • 34
    • 20
    • 18
    • 9
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 196
    • 22
    • 3
    Souris
    Clonalité
    • 180
    • 41
    Monoclonal
    Conjugué
    • 104
    • 18
    • 16
    • 14
    • 12
    • 10
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    Cet anticorp JNK est non-conjugé
    Application
    • 166
    • 93
    • 56
    • 43
    • 40
    • 39
    • 37
    • 31
    • 21
    • 18
    • 14
    • 12
    • 10
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
     Réactivité croisée
    Souris, Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Phosphorylated Human JNK/SAPK (pT183/pY185) Peptide
    Clone
    41-JNK-SAPK
    Isotype
    IgG1
    Top Product
    Discover our top product MAPK8 Anticorps primaire
  • Commentaires

    Related Products: ABIN968535, ABIN968632, ABIN967389, ABIN968074

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Fleming, Armstrong, Morrice, Paterson, Goedert, Cohen: "Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7." dans: The Biochemical journal, Vol. 352 Pt 1, Issue 3, pp. 145-54, (2001) (PubMed).

    Kyriakis, Avruch: "Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation." dans: Physiological reviews, Vol. 81, Issue 2, pp. 807-69, (2001) (PubMed).

    Muyembe, Maes, Makulu, Ghysels, Vandeven, Vandepitte: "The hem of the garment." dans: Seminars in dialysis, Vol. 14, Issue 1, pp. 76, (2001) (PubMed).

    Hinton, Henderson, Blanks, Rudnicka, Miller: "Monoclonal antibodies react with neuronal subpopulations in the human nervous system." dans: The Journal of comparative neurology, Vol. 267, Issue 3, pp. 398-408, (1988) (PubMed).

  • Antigène
    JNK (MAPK8) (Mitogen-Activated Protein Kinase 8 (MAPK8))
    Autre désignation
    JNK (MAPK8 Produits)
    Synonymes
    anticorps JNK, anticorps JNK-46, anticorps JNK1, anticorps JNK1A2, anticorps JNK21B1/2, anticorps PRKM8, anticorps SAPK1, anticorps SAPK1c, anticorps AI849689, anticorps Prkm8, anticorps BSK, anticorps BSK/DJNK, anticorps Bsk, anticorps CG5680, anticorps D-JNK, anticorps D-junk, anticorps DBSK/JNK, anticorps DJNK, anticorps DJNK/bsk, anticorps Dmel\\CG5680, anticorps JNK/SAPK, anticorps Jnk, anticorps Junk, anticorps SAPKa, anticorps c-Jun, anticorps dJNK, anticorps jnk, anticorps T10F20.15, anticorps jnk1, anticorps sapk1, anticorps mapk8, anticorps zgc:112379, anticorps JNKb, anticorps mapk8b, anticorps mitogen-activated protein kinase 8, anticorps Stress-activated protein kinase jnk-1, anticorps basket, anticorps Protein kinase superfamily protein, anticorps mitogen-activated protein kinase 8 L homeolog, anticorps mitogen-activated protein kinase 8b, anticorps mitogen-activated protein kinase 8B-like, anticorps MAPK8, anticorps jnk-1, anticorps Mapk8, anticorps bsk, anticorps ATMPK8, anticorps mapk8.L, anticorps mapk8b, anticorps LOC109094263
    Sujet
    The Ras signaling pathway links the signals from growth factor receptors with the activation of the MAPK kinase cascade of phosphorylation leading to cell growth and differentiation. External stimuli, like endotoxins, UV irradiation, heat, and hyperosmolarity, induce an array of cellular responses that culminate with gene expression, ultimately dictating an adaptation to the new environment. Small GTPases of the Rho family, including cdc42, Rac1, and Rho, transmit the stress signals that initiate the signal cascade. JNK is a c-Jun kinase that was also identified as SAPK1 and MAPKp49. JNK/SAPK, along with p38 and RK5/BMK1, comprise three classes of stress-activated MAPK groups. Complete activation of JNK/SAPK requires the phosphorylation of both Thr183 and Tyr185, which are located in a Thr-X-Tyr motif. The activation of these residues is believed to be carried out by MKK4 and MKK7. Active JNK/SAPK phosphorylates other kinases and multiple transcription factors that induce expression of genes, such as proinflammatory cytokines.
    Poids moléculaire
    43 & 56 kDa
    Pathways
    Signalisation MAPK, Signalisation WNT, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor, S100 Proteins
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