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OPA1 anticorps (AA 708-830)

OPA1 Reactivité: Humain, Souris, Rat, Poulet, Chien WB, IF Hôte: Souris Monoclonal 18-OPA1 unconjugated
N° du produit ABIN968892
  • Antigène Voir toutes OPA1 Anticorps
    OPA1 (Optic Atrophy 1 (Autosomal Dominant) (OPA1))
    Épitope
    • 15
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 708-830
    Reactivité
    • 47
    • 30
    • 30
    • 18
    • 17
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Poulet, Chien
    Hôte
    • 42
    • 5
    Souris
    Clonalité
    • 35
    • 12
    Monoclonal
    Conjugué
    • 20
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp OPA1 est non-conjugé
    Application
    • 31
    • 14
    • 14
    • 12
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Chien, Rat (Rattus), Souris, Poulet
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human OPA1 aa. 708-830
    Clone
    18-OPA1
    Isotype
    IgG1
    Top Product
    Discover our top product OPA1 Anticorps primaire
  • Commentaires

    Related Products: ABIN968586, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Alexander, Votruba, Pesch, Thiselton, Mayer, Moore, Rodriguez, Kellner, Leo-Kottler, Auburger, Bhattacharya, Wissinger: "OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28." dans: Nature genetics, Vol. 26, Issue 2, pp. 211-5, (2000) (PubMed).

    Delettre, Lenaers, Griffoin, Gigarel, Lorenzo, Belenguer, Pelloquin, Grosgeorge, Turc-Carel, Perret, Astarie-Dequeker, Lasquellec, Arnaud, Ducommun, Kaplan, Hamel: "Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy." dans: Nature genetics, Vol. 26, Issue 2, pp. 207-10, (2000) (PubMed).

  • Antigène
    OPA1 (Optic Atrophy 1 (Autosomal Dominant) (OPA1))
    Autre désignation
    OPA1 (OPA1 Produits)
    Synonymes
    anticorps 1200011N24Rik, anticorps AI225888, anticorps AI847218, anticorps lilr3, anticorps mKIAA0567, anticorps MGM1, anticorps NPG, anticorps NTG, anticorps largeG, anticorps fk62d06, anticorps wu:fb77a10, anticorps wu:fk62d06, anticorps zgc:92092, anticorps OPA1, mitochondrial dynamin like GTPase, anticorps optic atrophy 1 (autosomal dominant), anticorps Opa1, anticorps OPA1, anticorps opa1
    Sujet
    Three major GTP-binding protein families include trimeric and low molecular weight G-proteins, as well as a family of large proteins homologous to dynamin. The dynamin family contains proteins with diverse structure and function, but highly homologous N-terminal GTPase domains. A subgroup of the dynamin G-protein-binding family includes the mitochondrial proteins Drp1/Dnm1, Mgm1, and OPA1. The latter protein is mutated in dominant optic atrophy, a disease that involves loss of visual acuity and atrophy of the optic nerve. OPA1 is expressed in heart, brain, liver, and kidney. The sequence of OPA1 includes an N-terminal region that contains a mitochondrial targeting domain and three GTP-binding motifs. The overexpression of OPA1 in Cos-7 cells shows co-localization with cytochrome c in mitochondria, and leads to alterations in mitochondrial morphology from a characteristic tubuluar shape to a vesicular pattern. Thus, OPA1 may have roles in mitochondrial biogenesis that are critical for normal cell function. This antibody is routinely tested by western blot analysis.
    Poids moléculaire
    80-100 kDa
    Pathways
    Tube Formation
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