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BLK anticorps

BLK Reactivité: Humain WB, ELISA, ICC, FACS Hôte: Souris Monoclonal 1-00E-06 unconjugated
N° du produit ABIN968983
  • Antigène Voir toutes BLK Anticorps
    BLK (B Lymphoid Tyrosine Kinase (BLK))
    Reactivité
    • 65
    • 23
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 53
    • 9
    • 1
    Souris
    Clonalité
    • 55
    • 10
    Monoclonal
    Conjugué
    • 34
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp BLK est non-conjugé
    Application
    • 51
    • 36
    • 28
    • 13
    • 13
    • 8
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)
    Purification
    purified
    Immunogène
    Purified recombinant fragment of human BLK expressed in E. coli.
    Clone
    1-00E-06
    Isotype
    IgG1
    Top Product
    Discover our top product BLK Anticorps primaire
  • Indications d'application
    ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    4°C, -20°C for long term storage
  • Yang, Ng, Zhao, Hirankarn, Lau, Mok, Chan, Wong, Lee, Mok, Wong, Avihingsanon, Lee, Ho, Lee, Wong, Lau: "Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese." dans: Genes and immunity, Vol. 10, Issue 3, pp. 219-26, (2009) (PubMed).

    Borowiec, Liew, Thompson, Boonyasrisawat, Hu, Mlynarski, El Khattabi, Kim, Marselli, Rich, Krolewski, Bonner-Weir, Sharma, Sale, Mychaleckyj, Kulkarni, Doria: "Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 34, pp. 14460-5, (2009) (PubMed).

    Hom, Graham, Modrek, Taylor, Ortmann, Garnier, Lee, Chung, Ferreira, Pant, Ballinger, Kosoy, Demirci, Kamboh, Kao, Tian, Gunnarsson, Bengtsson, Rantapää-Dahlqvist, Petri, Manzi, Seldin, Rönnblom et al.: "Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. ..." dans: The New England journal of medicine, Vol. 358, Issue 9, pp. 900-9, (2008) (PubMed).

  • Antigène
    BLK (B Lymphoid Tyrosine Kinase (BLK))
    Autre désignation
    BLK (BLK Produits)
    Synonymes
    anticorps bltk, anticorps si:dkey-33i22.2, anticorps zgc:136231, anticorps MODY11, anticorps BLK proto-oncogene, Src family tyrosine kinase, anticorps B lymphoid kinase, anticorps blk, anticorps BLK, anticorps Blk
    Sujet

    Description: Blk is a Src family protein tyrosine kinase expressed in all stages of B cell development . Activation of B cells by various ligands is accompanied by activation of Blk . It has been suggested that Blk is involved in the control of B cell differentiation and proliferation . Blk transcripts have also been detected in human thymocytes, but not in mature T cells, implicating that Blk may play an important role in thymopoiesis . Blk function may be redundant, however, as mice that do not express Blk are not impaired with respect to B cell development and immune response .

    Aliases: MODY11, MGC10442, BLK

    Poids moléculaire
    58 kDa
    ID gène
    640
    HGNC
    640
    Pathways
    Positive Regulation of Peptide Hormone Secretion, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
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