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BTK anticorps

BTK Reactivité: Humain, Singe WB, ELISA, IHC, ICC Hôte: Souris Monoclonal 7F12H4 unconjugated
N° du produit ABIN968992
  • Antigène Voir toutes BTK Anticorps
    BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))
    Reactivité
    • 151
    • 90
    • 79
    • 13
    • 6
    • 4
    • 2
    Humain, Singe
    Hôte
    • 170
    • 12
    Souris
    Clonalité
    • 145
    • 38
    Monoclonal
    Conjugué
    • 71
    • 15
    • 12
    • 9
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    Cet anticorp BTK est non-conjugé
    Application
    • 109
    • 66
    • 40
    • 40
    • 36
    • 27
    • 18
    • 18
    • 10
    • 10
    • 9
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    Purification
    purified
    Immunogène
    Purified recombinant fragment of BTK expressed in E. coli.
    Clone
    7F12H4
    Isotype
    IgG1
    Top Product
    Discover our top product BTK Anticorps primaire
  • Indications d'application
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    4°C, -20°C for long term storage
  • Antigène
    BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))
    Autre désignation
    BTK (BTK Produits)
    Synonymes
    anticorps BTK, anticorps atk, anticorps bpk, anticorps xla, anticorps imd1, anticorps agmx1, anticorps psctk1, anticorps AGMX1, anticorps AT, anticorps ATK, anticorps BPK, anticorps IMD1, anticorps PSCTK1, anticorps XLA, anticorps AI528679, anticorps xid, anticorps Bruton tyrosine kinase, anticorps Bruton agammaglobulinemia tyrosine kinase, anticorps BTK, anticorps btk, anticorps Btk
    Sujet

    Description: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases.All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini.BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation.

    Aliases: BTK

    Poids moléculaire
    77 kDa
    ID gène
    695
    HGNC
    695
    Pathways
    Fc-epsilon Receptor Signaling Pathway, Hormone Transport, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, BCR Signaling
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