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CDK1 anticorps

CDK1 Reactivité: Humain WB, ELISA, IHC Hôte: Souris Monoclonal 8C5A6 unconjugated
N° du produit ABIN969033
  • Antigène Voir toutes CDK1 Anticorps
    CDK1 (Cyclin-Dependent Kinase 1 (CDK1))
    Reactivité
    • 321
    • 180
    • 116
    • 39
    • 35
    • 31
    • 25
    • 20
    • 15
    • 14
    • 12
    • 11
    • 11
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    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 268
    • 63
    Souris
    Clonalité
    • 255
    • 76
    Monoclonal
    Conjugué
    • 166
    • 27
    • 17
    • 15
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp CDK1 est non-conjugé
    Application
    • 263
    • 123
    • 66
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    • 54
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    • 49
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    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Purification
    purified
    Immunogène
    Purified recombinant fragment of CDC2 expressed in E. coli.
    Clone
    8C5A6
    Isotype
    IgG1
    Top Product
    Discover our top product CDK1 Anticorps primaire
  • Indications d'application
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    4°C, -20°C for long term storage
  • Meyer, Merkel, Brückl, Schellerer, Schildberg, Campean, Hohenberger, Croner: "Cdc2 as prognostic marker in stage UICC II colon carcinomas." dans: European journal of cancer (Oxford, England : 1990), Vol. 45, Issue 8, pp. 1466-73, (2009) (PubMed).

    Tang, Wu, Guo, Hansen, Perry, Freel, Nutt, Jackson, Kornbluth: "Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition." dans: Molecular biology of the cell, Vol. 19, Issue 8, pp. 3536-43, (2008) (PubMed).

  • Antigène
    CDK1 (Cyclin-Dependent Kinase 1 (CDK1))
    Autre désignation
    CDC2 (CDK1 Produits)
    Synonymes
    anticorps CDC2, anticorps CDC28A, anticorps P34CDC2, anticorps Cdc2, anticorps Cdc2a, anticorps p34, anticorps cdc2, anticorps wu:fc30e01, anticorps zgc:92032, anticorps PSTAIR, anticorps cdc-2, anticorps cdc2-a, anticorps cdc28a, anticorps cdc2x1.1, anticorps p34cdc2, anticorps xcdc2, anticorps 5363, anticorps CDCDm, anticorps CDK1, anticorps CDK1/CDC2, anticorps CG5363, anticorps Cdk-1, anticorps Cdk1, anticorps Dcdc2, anticorps Dm cdc2, anticorps DmCdc2, anticorps DmCdk1, anticorps Dmcdc2, anticorps Dmel\\CG5363, anticorps cdc, anticorps cdc2Dm, anticorps cdk1, anticorps dCdk1, anticorps group 4, anticorps l(2)31Eh, anticorps CDC2A, anticorps CDC2AAT, anticorps CDK2, anticorps CDKA1, anticorps CDKA;1, anticorps CYCLIN-DEPENDENT KINASE A;1, anticorps cell division control 2, anticorps cdc2-b, anticorps cdc2a, anticorps cdc2x1.2, anticorps POL3, anticorps pold, anticorps cyclin dependent kinase 1, anticorps cyclin dependent kinase like 1, anticorps Cell division control protein 2 1, anticorps cyclin-dependent kinase 1, anticorps cyclin-dependent kinase 1 S homeolog, anticorps Cyclin-dependent kinase 1, anticorps cell division control 2, anticorps cell division control protein2 homolog, anticorps cyclin-dependent kinase 1 L homeolog, anticorps polymerase (DNA directed), delta 1, catalytic subunit L homeolog, anticorps cyclin-dependent protein kinase Cdk1/Cdc2, anticorps CDK1, anticorps CDKL1, anticorps POPTR_0004s14080g, anticorps Cdk1, anticorps cdk1, anticorps cdk1.S, anticorps CDC2, anticorps cdc2, anticorps cdk-1, anticorps cdk1.L, anticorps pold1.L
    Sujet

    Description: The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.

    Aliases: CDC2, CDC28A, P34CDC2, MGC111195, DKFZp686L20222, CDK1

    Poids moléculaire
    34 kDa
    ID gène
    983
    HGNC
    983
    Pathways
    Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Toll-Like Receptors Cascades, Synthesis of DNA
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