CSK anticorps

N° du produit ABIN969069

Détail du produit anti-CSK anticorps

Antigène: CSK (C-Src tyrosine Kinase (CSK))

Reactivité: Humain, Souris, Rat, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CSK est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Purification: purified

Immunogène: Purified recombinant fragment of human CSK expressed in E. coli.

Clone: 5F3

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-CSK (ABIN969069)

Levy, Ehret, Rice, Verwoert, Launer, Dehghan, Glazer, Morrison, Johnson, Aspelund, Aulchenko, Lumley, Köttgen, Vasan, Rivadeneira, Eiriksdottir, Guo, Arking, Mitchell, Mattace-Raso, Smith, Taylor et al.: "Genome-wide association study of blood pressure and hypertension. ..." dans: Nature genetics, Vol. 41, Issue 6, pp. 677-87, (2010) (PubMed).

Ho, Levy, Rose, Johnson, Ridker, Chasman: "Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study." dans: Journal of hypertension, Vol. 29, Issue 1, pp. 62-9, (2010) (PubMed).

Kreil, Hochhaus, Cross, Chase: "A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias." dans: Leukemia research, Vol. 33, Issue 9, pp. e168-9, (2009) (PubMed).

Détails sur CSK

Antigène: CSK (C-Src tyrosine Kinase (CSK))

Autre désignation: CSK (CSK Produits)

Synonymes: anticorps AW212630, anticorps C-terminal Src kinase, anticorps c-src tyrosine kinase, anticorps CSK, non-receptor tyrosine kinase, anticorps CSK, anticorps Csk

Sujet:

Description: Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine. Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK . This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive. The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk .Tissue specificity: Expressed in lung and macrophages.

Aliases: MGC117393, CSK

Poids moléculaire: 50 kDa

ID gène: 1445

HGNC: 1445

Pathways: TCR Signaling, EGFR Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events