FCER2 anticorps

N° du produit ABIN969132

Détail du produit anti-FCER2 anticorps

Antigène: FCER2 (Fc Fragment of IgE, Low Affinity II, Receptor For (CD23) (FCER2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FCER2 est non-conjugé

Application: Flow Cytometry (FACS), ELISA

Purification: purified

Immunogène: Purified recombinant fragment of human FCER2 expressed in E. coli.

Clone: 5B5

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, FCM: 1:200 - 1:400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-FCER2 (ABIN969132)

Carvalho, Fullen, Lowe, Su, Ma: "Comparison of CD23 staining patterns in Merkel cell carcinoma and non-cutaneous small cell carcinoma." dans: Journal of cutaneous pathology, Vol. 36, Issue 2, pp. 206-10, (2009) (PubMed).

Shen, Vermeulen, Rajaraman, Menashe, He, Chapman, Yeager, Thomas, Burdett, Hutchinson, Yuenger, Chanock, Lan: "Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China." dans: Environmental and molecular mutagenesis, Vol. 50, Issue 4, pp. 285-90, (2009) (PubMed).

Détails sur FCER2

Antigène: FCER2 (Fc Fragment of IgE, Low Affinity II, Receptor For (CD23) (FCER2))

Autre désignation: FCER2 (FCER2 Produits)

Synonymes: anticorps BLAST-2, anticorps CD23, anticorps CD23A, anticorps CLEC4J, anticorps FCE2, anticorps IGEBF, anticorps Fcer2a, anticorps Fc fragment of IgE receptor II, anticorps FCER2, anticorps Fcer2

Sujet:

Description: The human leukocyte differentiation antigen CD23 (FCE2) is a key molecule for B-cell activation and growth. It is the low-affinity receptor for IgE. The truncated molecule can be secreted, then functioning as a potent mitogenic growth factor.(supplied by OMIM) . It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells), and can also be found on the surface of T cells, macrophages, platelets and EBV transformed B lymphoblasts. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is expressed by B cells in the follicular mantle but not by proliferating germinal centre cells. CD23 is also expressed by eosinophils. CD23 is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a ""membrane bound cytokine," in that the soluble cleavage products of CD23 are themselves able to act as cytokines in vitro.

Aliases: CD23, FCE2, CD23A, IGEBF, CLEC4J, FCER2

Poids moléculaire: 37 kDa

ID gène: 2208

HGNC: 2208

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process