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USP7 anticorps

USP7 Reactivité: Humain WB, ELISA Hôte: Souris Monoclonal 5F11 unconjugated
N° du produit ABIN969186
  • Antigène Voir toutes USP7 Anticorps
    USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
    Reactivité
    • 99
    • 35
    • 31
    • 8
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 89
    • 8
    • 2
    Souris
    Clonalité
    • 79
    • 20
    Monoclonal
    Conjugué
    • 48
    • 8
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp USP7 est non-conjugé
    Application
    • 78
    • 37
    • 30
    • 14
    • 14
    • 13
    • 12
    • 10
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Purification
    purified
    Immunogène
    Purified recombinant fragment of human HAUSP expressed in E. coli.
    Clone
    5F11
    Isotype
    IgG1
    Top Product
    Discover our top product USP7 Anticorps primaire
  • Indications d'application
    ELISA: 1:10000, WB: 1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    4°C, -20°C for long term storage
  • Becker, Marchenko, Maurice, Moll: "Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma." dans: Cell death and differentiation, Vol. 14, Issue 7, pp. 1350-60, (2007) (PubMed).

    Lu, Ma, Nguyen, Jones, Oren, Donehower: "The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop." dans: Cancer cell, Vol. 12, Issue 4, pp. 342-54, (2007) (PubMed).

  • Antigène
    USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
    Autre désignation
    HAUSP (USP7 Produits)
    Synonymes
    anticorps CG1490, anticorps Dmel\\CG1490, anticorps USP7, anticorps 2210010O09Rik, anticorps AA409944, anticorps AA617399, anticorps AU019296, anticorps AW548146, anticorps C80752, anticorps Hausp, anticorps HAUSP, anticorps TEF1, anticorps UBP, anticorps Ubiquitin-specific protease 7, anticorps ubiquitin carboxyl-terminal hydrolase 7, anticorps ubiquitin specific peptidase 7, anticorps Usp7, anticorps LOC100201254, anticorps USP7
    Sujet

    Description: USP7 or HAUSP is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP acitivity generally stabilizes its substrate proteins. HAUSP is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53.Normally, p53 levels are kept low in part due to Mdm2-mediated ubiquitylation and degradation of p53. Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress. Another important role of HAUSP function involves the oncogenic stabilization of p53. Oncogenes such as Myc and E1A are thought to activate p53 through a p19 alternative reading frame (p19ARF, also called ARF)-dependent pathway, although some evidence suggests ARF is not essential in this process. An intriguing possibility is that HAUSP provides an alternative pathway for safeguarding the cell against oncogenic insults.

    Aliases: TEF1, HAUSP, USP7

    Poids moléculaire
    128 kDa
    ID gène
    7874
    HGNC
    7874
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