KSHVORF45 anticorps

N° du produit ABIN969254

Détail du produit

Antigène: KSHVORF45

Reactivité: Human Herpesvirus 8 (HHV-8)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: purified

Immunogène: Purified recombinant fragment of KSHV ORF45 expressed in E. coli.

Clone: 2D4A5

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Référence

Zhu, Eisenach: "Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury." dans: Anesthesiology, Vol. 99, Issue 5, pp. 1175-9, (2003) (PubMed).

Zhu, Yuan: "The ORF45 protein of Kaposi's sarcoma-associated herpesvirus is associated with purified virions." dans: Journal of virology, Vol. 77, Issue 7, pp. 4221-30, (2003) (PubMed).

Zhu, King, Smith, Levy, Yuan: "A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 8, pp. 5573-8, (2002) (PubMed).

Détail du antigène

Antigène: KSHVORF45

Classe de substances: Viral Protein

Sujet:

Description: Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions

Aliases: ORF45

ID gène: 4961474

HGNC: 4961474