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CHEK1 anticorps

CHEK1 Reactivité: Humain, Souris WB, ELISA Hôte: Souris Monoclonal 2G1D5 unconjugated
N° du produit ABIN969476
  • Antigène Voir toutes CHEK1 Anticorps
    CHEK1 (Checkpoint Kinase 1 (CHEK1))
    Reactivité
    • 214
    • 118
    • 68
    • 16
    • 9
    • 9
    • 6
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Humain, Souris
    Hôte
    • 224
    • 13
    • 7
    • 5
    Souris
    Clonalité
    • 210
    • 40
    Monoclonal
    Conjugué
    • 134
    • 13
    • 11
    • 9
    • 9
    • 9
    • 9
    • 8
    • 8
    • 8
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    Cet anticorp CHEK1 est non-conjugé
    Application
    • 172
    • 86
    • 54
    • 41
    • 40
    • 36
    • 35
    • 17
    • 16
    • 13
    • 10
    • 7
    • 6
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA
    Purification
    purified
    Immunogène
    Purified recombinant fragment of CHK1 expressed in E. coli.
    Clone
    2G1D5
    Isotype
    IgG1
    Top Product
    Discover our top product CHEK1 Anticorps primaire
  • Indications d'application
    ELISA: 1:10000, WB: 1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS containing 0.03 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    4°C, -20°C for long term storage
  • OConnell, Raleigh, Verkade, Nurse: "Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation." dans: The EMBO journal, Vol. 16, Issue 3, pp. 545-54, (1997) (PubMed).

  • Antigène
    CHEK1 (Checkpoint Kinase 1 (CHEK1))
    Autre désignation
    CHK1 (CHEK1 Produits)
    Synonymes
    anticorps An08g10320, anticorps AO090003000441, anticorps CHK1, anticorps chk1, anticorps C85740, anticorps Chk1, anticorps rad27, anticorps id:ibd2720, anticorps zgc:56093, anticorps CHEK1, anticorps checkpoint kinase 1, anticorps serine/threonine-protein kinase chk1, anticorps serine/threonine-protein kinase Chk1, anticorps CAMK/CAMKL/CHK1 protein kinase Chk1, anticorps checkpoint kinase 1 S homeolog, anticorps CHEK1, anticorps ANI_1_2436074, anticorps AOR_1_768154, anticorps PTRG_04183, anticorps SJAG_01680, anticorps PAAG_04978, anticorps MCYG_03290, anticorps VDBG_03742, anticorps chek1.S, anticorps Chek1, anticorps chek1
    Sujet

    Description: CHK1, also known as CHEK1, it is a kinase that phosphorylates cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. Cdc25, when phosphorylated on serine 216 by chk1 becomes bound by an adaptor protein in the cytoplasm. Therefore it is inhibited from removing the inhibiting phosphate from MPF (mitotic/maturation promoting factor) added by Wee1. Consequently, a cell is prevented from entering mitosis. Chk1 can also phosphorylate p53 at Ser20 in vitro.

    Aliases: CHEK1

    Poids moléculaire
    56 kDa
    ID gène
    1111
    HGNC
    1111
    Pathways
    Signalisation p53, Apoptose, Cycle Cellulaire, Réparation de l'ADN
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