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Doublecortin anticorps (AA 362-411)

DCX Reactivité: Humain WB, ELISA, IHC, ICC, FACS Hôte: Souris Monoclonal 2G5 unconjugated
N° du produit ABIN969513
  • Antigène Voir toutes Doublecortin (DCX) Anticorps
    Doublecortin (DCX)
    Épitope
    • 7
    • 7
    • 7
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 362-411
    Reactivité
    • 110
    • 73
    • 67
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 102
    • 11
    • 2
    • 2
    Souris
    Clonalité
    • 97
    • 20
    Monoclonal
    Conjugué
    • 64
    • 9
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Doublecortin est non-conjugé
    Application
    • 74
    • 40
    • 32
    • 13
    • 12
    • 11
    • 8
    • 8
    • 7
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)
    Purification
    purified
    Immunogène
    Purified recombinant fragment of human DCX (AA: 362-411) expressed in E. coli. ,
    Clone
    2G5
    Isotype
    IgG1
  • Indications d'application
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    4°C, -20°C for long term storage
  • Evangelisti, Florian, Massimi, Dominici, Giannini, Galardi, Buè, Massalini, McDowell, Messi, Gulino, Farace, Ciafrè: "MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 23, Issue 12, pp. 4276-87, (2009) (PubMed).

  • Antigène
    Doublecortin (DCX)
    Autre désignation
    DCX (DCX Produits)
    Synonymes
    anticorps DCX, anticorps DBCN, anticorps DC, anticorps LISX, anticorps SCLH, anticorps XLIS, anticorps Dbct, anticorps 18C15.5, anticorps doublecortin, anticorps DCX, anticorps Dcx
    Sujet

    Description: This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

    Aliases: DC, DBCN, LISX, SCLH, XLIS

    Poids moléculaire
    49.3 kDa
    ID gène
    1641
    HGNC
    1641
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