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IKK alpha anticorps (C-Term)

Name: IKK alpha anticorps (C-Term)
SKU: ABIN116874
Availability: InStock

Cet anticorps anti-IKK alpha Polyclonal Lapin (ABIN116874) détecte spécifiquement IKK alpha dans WB, IP et EIA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

N° du produit ABIN116874

1.147,69 €

Plus frais de livraison 40,00 € et TVA

0.1 mL

Destination: France

Envoi sous 17 jours ouvrables

Aperçu rapide pour IKK alpha anticorps (C-Term) (ABIN116874)

Antigène

Voir toutes IKK alpha (CHUK) Anticorps

IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Reactivité

Humain, Souris, Rat

Hôte

Lapin

Clonalité

Polyclonal

Conjugué

Cet anticorp IKK alpha est non-conjugé

Application

Western Blotting (WB), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

Discover our top product CHUK Anticorps primaire

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C-Term

Specificité

Anti-IKKa may react non-specifically with other proteins. Control peptide will compete only with the specific reaction of antiserum with the IKKa subunit.

Purification

Prepared from monospecific antiserum by delipidation and defibrination.

Immunogène

IKKa peptide corresponding to the highly conserved C-terminus region of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (C-Term) antibody
CHUK Reactivité: Humain WB, IHC, IF, IP Hôte: Lapin Polyclonal unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (pSer176), (pSer177) antibody
CHUK Reactivité: Humain, Souris, Rat WB, IHC, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (AA 646-745) antibody
CHUK Reactivité: Humain WB, ELISA, IF, IHC (p) Hôte: Souris Monoclonal 4B8 unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) antibody
KD Validated CHUK Reactivité: Humain WB, FACS Hôte: Lapin Monoclonal 23GB765 unconjugated Recombinant Antibody

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) antibody
KD Validated CHUK Reactivité: Humain WB, FACS Hôte: Lapin Monoclonal 23GB1065 unconjugated Recombinant Antibody

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (AA 646-745) antibody
CHUK Reactivité: Humain WB, ELISA, IF, PLA Hôte: Souris Monoclonal 1F8 unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (pThr23) antibody
CHUK Reactivité: Humain, Souris, Rat WB, IHC, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) antibody
CHUK Reactivité: Humain WB, ELISA, ICC, FACS Hôte: Souris Monoclonal 3G12H9 unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (AA 411-745) antibody
CHUK Reactivité: Humain, Souris, Rat WB, IHC (p) Hôte: Lapin Polyclonal unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (AA 411-745) antibody
CHUK Reactivité: Humain WB, IHC Hôte: Lapin Polyclonal unconjugated

Indications d'application

Suitable for Immunoprecipitation, Immunoblotting and ELISA. Recommended Dilutions: This product was assayed by immunoblot and found to bereactive against IKKa at a dilution of 1: 1000 followed by reaction with Peroxidaseconjugated Affinity Purified anti-Rabbit IgG [H&L] (Goat). Anti-IKKa is suitable for thedetection by immunoblot of human, mouse and rat IKKa showing an 85 kDa band.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions

For Research Use only
Format

Liquid

Concentration

80.0 mg/mL (by Refractometry)

Conseil sur la manipulation

Avoid repeated freezing and thawing.

Stock

4 °C/-20 °C

Stockage commentaire

Store lyophilized product at 2-8 °C. After reconstitution, store at -20 °C.
Antigène

IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Autre désignation

IKKA

Sujet

NFk B comprises a family of cellular transcription factors that are involved in the inducible expression of a variety of cellular genes that regulate the inflammatory response and control of cell death. In the cytoplasm NFk B is negatively modulated by the inhibitory proteins Ik B. In turn Ik B is phosphorylated by a cellular kinase complex called IKK. IKK is a heterodimer composed of two kinases: IKK-a and IKK-b that phosphorylate Ik B leading to its degradation and the resulting translocation of NFk B to the nucleus. IKK kinase activity is modulated negatively by pharmaceutical agents such as aspirin and positively by various cellular components such as TNF-a , endotoxins and overexpression of cellular kinases like MEKK1. Aspirin appears to have its effect by inhibiting the binding of ATP to IKK.Synonyms: CHUK, Conserved helix-loop-helix ubiquitous kinase, I kappa-B kinase alpha, I-kappa-B kinase 1, IKK-A, IKK-alpha, IKK1, IkBKA, IkappaB kinase, Inhibitor of nuclear factor kappa-B kinase subunit alpha, NFKBIKA, Nuclear factor NF-kappa-B inhibitor kinase alpha, TCF16

ID gène

1147

NCBI Accession

NP_001269

UniProt

O15111

Pathways

Signalisation PI3K-Akt, Signalisation NF-kappaB, Signalisation RTK, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins