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anti-Human DFFA Anticorps:
anti-Mouse (Murine) DFFA Anticorps:
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Human Monoclonal DFFA Primary Antibody pour IF, WB - ABIN968331
Fulda, Meyer, Debatin: Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression. dans Oncogene 2002
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Mouse (Murine) Polyclonal DFFA Primary Antibody pour WB - ABIN967295
Enari, Sakahira, Yokoyama, Okawa, Iwamatsu, Nagata: A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. dans Nature 1998
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Human Polyclonal DFFA Primary Antibody pour ELISA, ICC - ABIN4305087
Nagata, Kishi, Liu, Matsuda, Imanaka, Tsukada, Kang, Muraguchi: The regulation of DNAse activities in subcellular compartments of activated thymocytes. dans Immunology 2002
Mouse (Murine) Polyclonal DFFA Primary Antibody pour WB - ABIN222902
Boulares, Zoltoski, Yakovlev, Xu, Smulson: Roles of DNA fragmentation factor and poly(ADP-ribose) polymerase in an amplification phase of tumor necrosis factor-induced apoptosis. dans The Journal of biological chemistry 2001
Data show that the caspase-activated DNase (CAD (Montrer DFFB Anticorps)) is activated when caspases cleave its endogenous inhibitor ICAD, resulting in the characteristic DNA laddering of apoptosis.
Data suggest that DFF45 gene silencing, when applied in combination with doxorubicin, may offer a therapeutic strategy for the treatment of breast cancer.
ICAD deficiency was associated with severe genomic instability.
mRNA splicing is actively driven toward the pro-apoptotic isoforms of Bim (Montrer BCL2L11 Anticorps), Bcl-x (Montrer BCL2L1 Anticorps), and ICAD in Pnn (Montrer PNN Anticorps)-depleted MCF-7 cells.
The DFF45 level in human endometrium corresponds to the respective phase of the menstrual cycle and decreases significantly after menopause.
study reveals a previously unrecognized function of miR (Montrer MLXIP Anticorps)-145 in DFF45 processing, which may underlie crucial aspects of cancer biology
The heterodimer, DFF40 (Montrer DFFB Anticorps)-DFF45, is localized to the chromatin fraction under apoptotic as well as non-apoptotic conditions.
DFF45 at chromosome 1 reveal rare allelic variants in neuroblastoma (Montrer ARHGEF16 Anticorps) tumors
NMR solution structure of the C-terminal domain of DFF45, which is essential for its chaperone-like activity
Hypoxia-induced cleavage of caspase-3 (Montrer CASP3 Anticorps) and DFF45/ICAD in human failed cardiomyocytes.
Co-transfection of mouse DFF45(-/-) fibroblasts with plasmids encoding human DFF40 (Montrer DFFB Anticorps) and DFF45 reversed the apoptosis resistance normally observed in these cells
a lack of DFF45 facilitates hippocampus-dependent nonspatial memory, as well as hippocampus-dependent spatial memory
apoptotic DNA fragmentation factor is required for the maintenance of genetic stability and may play a role in tumor suppression
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, DNA fragmentation factor 45 kDa subunit
, DNA fragmentation factor subunit alpha
, inhibitor of CAD
, DNA fragmentation factor, 45kDa, alpha polypeptide