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Overexpression of SET-Nup214 (Montrer NUP214 Kits ELISA) in HeLa cells leads to the formation of similar nuclear bodies that recruit CRM1 (Montrer XPO1 Kits ELISA), export cargo proteins, and certain nucleoporins and concomitantly affect nuclear protein (Montrer RDBP Kits ELISA) and poly(A)(+) RNA export.
Molecular chaperone (Montrer HSP90AA1 Kits ELISA) SET-assisted eviction of linker histones and Shugoshins is a fundamental step in mammalian mitotic progression.
Our findings suggested the oncogenic role of SET and the adverse prognostic value of SET overexpression in hepatocellular carcinoma (HCC (Montrer FAM126A Kits ELISA)). This alteration defines a subgroup of HCC (Montrer FAM126A Kits ELISA) patients who could benefit from SET antagonists, such as EMQA.
This review summarizes and discusses the general mechanisms of H3K4 methylation, and how the six main enzymes from the SET/MLL (Montrer MLL Kits ELISA) family (responsible for H3K4me1/me2 (Montrer CELSR1 Kits ELISA)/me3 (Montrer ME3 Kits ELISA)) function in hematopoiesis and in hematologic malignancies. [review]
identification of the oncoprotein SET as a major cellular factor whose binding with p53 (Montrer TP53 Kits ELISA) is dependent on C-terminal domain acetylation status
Data indicate that SET protein as a direct target of microRNA miR (Montrer MLXIP Kits ELISA)-125b, and the downregulation of SET, observed during tumor migration, was affected by the overexpression of miR125b.
significance of SET/I2PP2A-mediated PP2A and non-PP2A pathways in polycystic ovary syndrome
Data show that downregulating proto-oncogene (Montrer RAB1A Kits ELISA) protein Akt (p-Akt (Montrer AKT1 Kits ELISA)) by inhibiting PP2A (Montrer PPP2R4 Kits ELISA) inhibitor SET-mediated protein phosphatase 2A (PP2A (Montrer PPP2R4 Kits ELISA)) inactivation determined the pro-apoptotic effects of EMQA and paclitaxel combination treatment.
Data suggest a critical role for the I2PP2A protein (SET)-protein phosphatase-2A (PP2A) signaling axis in Pten protein (Pten) deficient castration resistant prostate cancer (CRPC) progression.
Data show that the biogical effect of inhibitor-2 of protein phosphatase-2A (SET) on proliferation and invasion was mediated by the inhibition of the protein phosphatase 2A (PP2A).
The presence of full-length SET in the neuronal cytoplasm is sufficient to impair PP2A methylation and activity, leading to tau hyperphosphorylation.
SET/PP2A system regulates testosterone production in ovarian follicles in vitro.
SET played a positive role in regulating ovarian androgen biosynthesis by enhancing the transcription of steroidogenic enzymes CYP17A1 (Montrer CYP17A1 Kits ELISA) and HSD3B2 (Montrer HSD3B2 Kits ELISA), which maybe contribute to the hyperandrogenism in polycystic ovary syndrome
study found SET, a putative oncogene (Montrer RAB1A Kits ELISA) was significantly downregulated in a bisphenol A dose-dependent manner; from gene network analysis, SET is predicted to communicate with other genes including CYP17 (Montrer CYP17A1 Kits ELISA), which is involved in biosynthesis and metabolism of sex-hormones
Our results suggest that the increased I(2)(PP2A) may trigger apoptosis by p53 (Montrer TP53 Kits ELISA) upregulation, but due to simultaneous activation of Akt (Montrer AKT1 Kits ELISA), the neurons are aborted from the apoptotic pathway.
SET is an important regulator of chromosome condensation/decondensation and that disruption of the MCPH1 (Montrer MCPH1 Kits ELISA)-SET interaction might be important for the pathogenesis of primary microcephaly
By a novel molecular mechanism, apolipoprotein (apo)E/peptide enhances protein phosphatase 2A (PP2A) activity within a cell by binding/forming a complex with SET, reducing the amount of SET available to inhibit PP2A, signaling, and inflammatory response.
These studies indicated that the TAF (Montrer TAF8 Kits ELISA)-Ialpha promoter is under the control of Sp1 (Montrer SP1 Kits ELISA).(TAF (Montrer TAF8 Kits ELISA)-Ialpha )
The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene.
protein phosphatase 2A inhibitor 2-like
, HLA-DR-associated protein II
, SET translocation (myeloid leukemia-associated)
, Template-Activating Factor-I, chromatin remodelling factor
, inhibitor of granzyme A-activated DNase
, inhibitor-2 of protein phosphatase-2A
, phosphatase 2A inhibitor I2PP2A
, protein SET
, protein phosphatase type 2A inhibitor
, SET translocation
, template-activating factor I
, liver regeneration-related protein LRRGR00002