anti-Rat (Rattus) XIAP anticorps pour Immunohistochemistry (Paraffin-embedded Sections)

Recommended XIAP Antibody (fourni par: Connectez-vous pour afficher )

Antigène
X-Linked Inhibitor of Apoptosis (XIAP) Anticorps
  • BIRC4
  • api3
  • birc4
  • ilp1
  • miha
  • xlp2
  • xxiap
  • API3
  • IAP-3
  • ILP1
  • MIHA
  • XLP2
  • hIAP-3
  • hIAP3
  • 1110015C02Rik
  • Aipa
  • Api3
  • Birc4
  • IAP3
  • ILP-1
  • mXIAP
  • riap3
  • X-linked inhibitor of apoptosis
  • XIAP
  • xiap
  • Xiap
Épitope
AA 230-280
21
18
14
9
9
8
8
6
5
5
5
4
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
185
93
61
7
5
5
2
Hôte
Lapin
159
26
1
Clonalité
Polyclonal
Conjugué
Cet anticorp XIAP est non-conjugé
6
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
162
72
53
45
31
23
12
12
9
9
3
3
2
1
1
Options
Fournisseur
Connectez-vous pour afficher
Supplier Product No.
Connectez-vous pour afficher
Request

Recevoir ce produit gratuitement

Envoyez-nous votre proposition de validation. J'aimerais valider ce produit

Savoir plus

Images

N° du produit ABIN674364
315,94 €
Plus frais de livraison 40,00 € et TVA
Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
1 ABIN272094 IHC (p) WB Rabbit Connectez-vous pour afficher Polyclonal
1 ABIN127043 IHC (p) IP WB Rabbit Connectez-vous pour afficher Polyclonal
1 ABIN3044425 IHC (p) WB Rabbit IgG AA 14-34, N-Term Connectez-vous pour afficher Polyclonal 3
1 ABIN2888718 IHC (p) ELISA WB Rabbit IgG AA 53-102 Connectez-vous pour afficher Polyclonal
1 ABIN957244 IHC (fro) IHC (p) IP WB Rabbit AA 163-230 Connectez-vous pour afficher Polyclonal
1 ABIN957246 IHC (fro) IHC (p) IP WB Rabbit AA 163-230 Connectez-vous pour afficher Polyclonal
1 ABIN957245 IHC (fro) IHC (p) IP WB Rabbit AA 163-230 Connectez-vous pour afficher Polyclonal
1 ABIN957247 IHC (fro) IHC (p) IP WB Rabbit AA 163-230 Connectez-vous pour afficher Polyclonal
1 ABIN674373 IHC (p) WB HRP Rabbit IgG AA 230-280 Connectez-vous pour afficher Polyclonal
1 ABIN4366393 IHC IHC (p) IP WB Rabbit BIR2 Domain Connectez-vous pour afficher Polyclonal 2
1 ABIN674366 IHC (p) WB Biotin Rabbit IgG AA 230-280 Connectez-vous pour afficher Polyclonal
1 ABIN2891845 IHC (p) WB Rabbit Gly81 Connectez-vous pour afficher Polyclonal
1 ABIN3029643 IHC (p) WB Rabbit IgG N-Term Connectez-vous pour afficher Polyclonal
1 ABIN4366390 IHC IHC (p) IP WB Rabbit BIR2 Domain Connectez-vous pour afficher Polyclonal
1 ABIN4366392 IHC IHC (p) IP WB Rabbit BIR2 Domain Connectez-vous pour afficher Polyclonal
1 ABIN4366388 IHC IHC (p) IP WB Rabbit BIR2 Domain Connectez-vous pour afficher Polyclonal
1 ABIN4366387 IHC IHC (p) WB Rabbit Connectez-vous pour afficher Polyclonal
1 ABIN4366389 IHC IHC (p) IP WB Rabbit BIR2 Domain Connectez-vous pour afficher Polyclonal
1 ABIN4366391 IHC IHC (p) IP WB Rabbit BIR2 Domain Connectez-vous pour afficher Polyclonal
1 ABIN537435 IHC (fro) IHC (p) IP WB Rabbit Connectez-vous pour afficher Polyclonal

General

Antigène X-Linked Inhibitor of Apoptosis (XIAP) Anticorps
Épitope AA 230-280
(21), (18), (14), (9), (9), (8), (8), (6), (5), (5), (5), (4), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivité Humain, Souris, Rat (Rattus)
(185), (93), (61), (7), (5), (5), (2)
Hôte Lapin
(159), (26), (1)
Clonalité
Polyclonal
Conjugué Cet anticorp XIAP est non-conjugé
(6), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(162), (72), (53), (45), (31), (23), (12), (12), (9), (9), (3), (3), (2), (1), (1)
Pubmed 4 références disponible
Fournisseur Connectez-vous pour afficher

Détail du produit anti-XIAP anticorps

Détail du antigène XIAP Information d'application Stockage ProductDetails: References for anti-XIAP antibody (ABIN674364) Images
Purification Purified by Protein A.
Immunogène KLH conjugated synthetic peptide derived from mouse XIAP
Isotype IgG

Détail du antigène XIAP

Détail du produit anti-XIAP anticorps Information d'application Stockage ProductDetails: References for anti-XIAP antibody (ABIN674364) Images Haut de la page
Antigène
Autre désignation Xiap (XIAP Antibody Extrait)
Sujet

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program.

Subcellular location: Cytoplasm, Nucleus

Synonyms: Aipa, Api3, IAP3, MIHA, Birc4, ILP-1, 11115C2Rik, E3 ubiquitin-protein ligase XIAP, Baculoviral IAP repeat-containing protein 4, IAP homolog A, Inhibitor of apoptosis protein 3, IAP-3, mIAP-3, mIAP3, X-linked inhibitor of apoptosis protein, X-linked IAP, Xiap

ID gène 11798
UniProt Q60989
Pathways Apoptose, Caspase Cascade in Apoptosis, Transition Metal Ion Homeostasis

Information d'application

Détail du produit anti-XIAP anticorps Détail du antigène XIAP Stockage ProductDetails: References for anti-XIAP antibody (ABIN674364) Images Haut de la page
Indications d'application WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200
Restrictions For Research Use only

Stockage

Détail du produit anti-XIAP anticorps Détail du antigène XIAP Information d'application ProductDetails: References for anti-XIAP antibody (ABIN674364) Images Haut de la page
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20°C
Date de péremption 12 months

ProductDetails: References for anti-XIAP antibody (ABIN674364)

Détail du produit anti-XIAP anticorps Détail du antigène XIAP Information d'application Stockage Images Haut de la page
Produit citée dans:

Sun, Liu, Zou, Lan, Sun, Wang, Zhao, Jiang, Liu: "Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer." dans: Journal of bioenergetics and biomembranes, 2015

Jin, Lan, Han, Sun, Liu, Zhang, Liu, Zhang, Hu, Liu, Wang: "Smac mimetic?induced caspase?independent necroptosis requires RIP1 in breast cancer." dans: Molecular medicine reports, 2015

Chen, Xie, Zhao, Wang, Bai, Yin, Jiang, Xie, Jia, Huang et al.: "Ampelopsin induces apoptosis by regulating multiple c?Myc/S?phase kinase?associated protein 2/F?box and WD repeat?containing protein 7/histone deacetylase 2 pathways in human lung adenocarcinoma ..." dans: Molecular medicine reports, Vol. 11, Issue 1, pp. 105-12, 2014 Méthode utilisée: Western Blotting (WB) (Échantillon (espèces): Human).

Chen, Bai, Zhong, Xie, Long, Yang, Wu, Jia, Wang: "Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7? and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549." dans: PLoS ONE, Vol. 8, Issue 11, pp. e79201, 2013

Images

Détail du produit anti-XIAP anticorps Détail du antigène XIAP Information d'application Stockage ProductDetails: References for anti-XIAP antibody (ABIN674364) Haut de la page
Supplier Images
Immunohistochemistry (IHC) image for anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 230-280) antibody (ABIN674364) Formalin-fixed and paraffin embedded human endometrial tissue labeled with Anti-XIAP/...
Immunofluorescence (Cultured Cells) (IF (cc)) image for anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 230-280) antibody (ABIN674364) Image provided by One World Lab validation program. MCF-7 cells probed with Rabbit An...
Immunofluorescence (Cultured Cells) (IF (cc)) image for anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 230-280) antibody (ABIN674364) Image provided by One World Lab validation program. A549 cells probed with Rabbit Ant...