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can act as a negative mediator in autophagy through stimulation of the AKT (Montrer AKT1 Kits ELISA)-MTORC1 pathway and direct interaction with LC3.
Data show that p62 interaction with LC3, leading to the delivery of p62 and its cargoes to the autophagosome.
LC3 puncta were still present in the granular layer of nonlesional psoriatic epidermis but at a much lower level compared with healthy adult epidermis, whereas in lesional psoriatic skin, LC3 was not expressed at all.
Results suggest that P. gingivalis internalization is not necessary for LC3 lipidation.
Development of LC3/GABARAP (Montrer GABARAP Kits ELISA) sensors containing a LIR (Montrer CD300C Kits ELISA) and a hydrophobic domain to monitor autophagy.
Aldo was revealed to induce autophagy, as indicated by the increased conversion from microtubuleassociated protein 1A/1Blight chain 3 (LC3)I to LC3II, the increased expression levels of autophagyrelated gene 7 (Atg7) and the increased degradation of p62, which was accompanied by MC proliferation
LC3 overexpression is associated with colorectal cancer.
these findings were reversed with the LC3I/II-shPTEN treatment. Therefore, the loss of PTEN may promote the development of primary resistance to trastuzumab in breast cancer via autophagy defects
autophagy of cytoplasmic bulk cargo was completely LC3 independent.
Results of our present study demonstrated that beclin 1 (Montrer BECN1 Kits ELISA) and LC3 immunoreactivity increased in carcinoma cells following exemestane treatment and that the status of pre-treatment stromal beclin 1 (Montrer BECN1 Kits ELISA) is associated with higher carcinoma cell proliferation and poor clinical and pathological responses to NAE
paxillin (Montrer PXN Kits ELISA) interacts with processed LC3 through a conserved LIR (Montrer CD300C Kits ELISA) motif in the amino-terminal end of paxillin (Montrer PXN Kits ELISA) and that this interaction is regulated by oncogenic SRC (Montrer SRC Kits ELISA) activity.
These results suggest that the Golgi complex may serve as a membrane platform for noncanonical autophagy where V-ATPase (Montrer ATP6V1H Kits ELISA) is (Montrer ATP11A Kits ELISA) a key player.
LC3 was down regulated in the hypothalamus of diabetic mice.
LC3 overexpression in 3T3-L1 preadipocytes stimulates adipocyte differentiation via direct modulation of RKIP (Montrer PEBP1 Kits ELISA)-dependent ERK1 (Montrer MAPK3 Kits ELISA) activity.
These findings demonstrate that LC3 contributes to melanogenesis by increasing ERK (Montrer EPHB2 Kits ELISA)-dependent MITF (Montrer MITF Kits ELISA) expression, thereby providing a mechanistic insight into the signaling network that links autophagy to melanogenesis.
LC3 is exploited by coxsackievirus in both autophagy-dependent and -independent manners in vivo
LC3 overexpression thus exerts neuroprotection through increasing alpha7nAChR expression for eAbeta binding and further enhancing autophagic activity for Abeta (Montrer APP Kits ELISA) clearance in vitro and in vivo.
we describe basic protocols to measure the levels of endogenous LC3 and p62 by immunoblotting in cultured mammalian cells
Clusterin (Montrer CLU Kits ELISA) facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival.
Hedgehog (Montrer SHH Kits ELISA) signaling is required for the Lc3 synthase (Montrer B3GNT5 Kits ELISA) expression in embryonic lens
LC3 is localized in porcine oocytes during in vitro maturation.
Data suggest that expression of MAP1LC3A in graafian follicle/granulosa cell/theca cell is distinct in normal pigs versus miniature pigs; expression of MAP1LC3A is higher in normal pigs than in miniature pigs; MAP1LC3A may be marker of autophagy.
Data indicate that the expression of MAP1LC3A, B and autophagy-associated genes (ATG5 (Montrer ATG5 Kits ELISA), mTOR (Montrer FRAP1 Kits ELISA), Beclin-1 (Montrer BECN1 Kits ELISA)) was increased in normal pigs, while decreased in miniature pigs.
MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis.
microtubule-associated protein 1 light chain 3 alpha
, 35-alpha calcimedin
, Annexin III (Lipocortin III)
, lipocortin III
, placental anticoagulant protein III
, MAP1 light chain 3-like protein 1
, MAP1A/1B light chain 3 A
, MAP1A/MAP1B LC3 A
, MAP1A/MAP1B light chain 3 A
, autophagy-related ubiquitin-like modifier LC3 A
, microtubule-associated proteins 1A/1B light chain 3
, microtubule-associated proteins 1A/1B light chain 3A
, autophagy-related protein LC3 A
, microtubule-associated protein 1-light chain 3A
, microtubule-associated proteins 1A/1B light chain 3B
, UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5A
, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
, beta-1,3-N-acetylglucosaminyltransferase 5A
, lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase A
, lactotriaosylceramide synthase A
, lc(3)Cer synthase A
, lc3 synthase A