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In conclusion, our data demonstrated that UFM24 inhibits oxidative burst in human neutrophils through inhibition of PDE4 activity. UFM24 also exhibited significant protection against endotoxin-induced acute lung injury (ALI)in mice. UFM24 has potential as an anti-inflammatory agent for treating neutrophilic lung damage.
PDE4 inhibition reduces neointima formation and inhibits VCAM-1 (Montrer VCAM1 Kits ELISA) expression and histone methylation in an Epac (Montrer RAPGEF3 Kits ELISA)-dependent manner.
results suggest that PDE4A may be important in the regulation of emotional memory and anxiety-like behavior, but not emesis
This study showed that long PDE4 isoforms provide a novel node for cross-talk between the cAMP and p38 MAPK (Montrer MAPK14 Kits ELISA) signalling systems at the level of MK2 (Montrer KCNA2 Kits ELISA).
Increased cAMP may remodel cAMP-mediated signalling events by not only increasing the expression of specific PDE4 cAMP phosphodiesterases but also by down-regulating specific isoforms, such as is shown here for PDE4A10 in cardiac myocytes.
a new mechanism in which phosphodiesterase PDE4A4/5 interacts with p75(NTR (Montrer NGFR Kits ELISA)) to enhance cAMP degradation
Repurposing the PDE4 inhibitor roflumilast for treatment of B-cell malignancies is safe, suppresses the oncogenic PI3K (Montrer PIK3CA Kits ELISA)/AKT (Montrer AKT1 Kits ELISA) kinases, and may be clinically active
The expression of PDE4A4 and PDE4A8 in normal pituitary, their increased expression in adenomatous pituitary cells where AIP (Montrer AIP Kits ELISA) is meant to participate, and the disruption of the PDE4A4-AIP (Montrer AIP Kits ELISA) interaction by AIP (Montrer AIP Kits ELISA) mutants may play a role in pituitary tumorigenesis.
the well-known interaction between AIP (Montrer AIP Kits ELISA) and 2 different isoforms of phosphodiesterases (PDEs), PDE2A3 and PDE4A5, is of particular interest. While the interaction with over-expressed AIP (Montrer AIP Kits ELISA) does not seem to affect PDE2A3 function, the reported effect on PDE4A5 is, in contrast, reduced enzymatic activity.
Low PDE4A expression is associated with sepsis.
Findings demonstrate loss of PDE4 expression in the striato-thalamo-cortical circuit, which is associated with deficits of spatial working memory in patients with Parkinson disease.
A multifunctional docking site on the catalytic unit of PDE4 that is utilized by multiple interaction partners has been identified.
curcumin exerts its in vitro anti-angiogenic and in vivo anti-tumour properties through combined PDE2 (Montrer PDE2A Kits ELISA) and PDE4 inhibition
After 48 h yessotoxin treatment PDE4A-dependent autophagy, as non-apoptotic programmed cell death, is activated.
AKAP 149 (Montrer AKAP1 Kits ELISA)-PKA-PDE4A complex localization is related with YTX effect in K-562 cell line
Hydroxycarbamide decreases sickle reticulocyte adhesion to resting endothelium by inhibiting endothelial lutheran/basal cell adhesion molecule (Lu/BCAM (Montrer BCAM Kits ELISA)) through phosphodiesterase 4A activation.
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
phosphodiesterase 4A, cAMP-specific
, phosphodiesterase 4A-like
, phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)
, cyclic AMP-specific phosphodiesterase FCPDE4A1A
, cyclic AMP-specific phosphodiesterase OCPDE4A1A
, phosphodiesterase 4A, cAMP specific
, cyclic AMP-specific phosphodiesterase CPPDE4A1A
, cAMP-specific 3',5'-cyclic phosphodiesterase 4A
, cAMP-specific phosphodiesterase PDE4A
, cyclic AMP specific phosphodiesterase PDE4A5A
, phosphodiesterase 4A, cAMP-specific (dunce
, phosphodiesterase E2 dunce homolog, Drosophila
, phosphodiesterase isozyme 4
, cyclic AMP-specific phosphodiesterase SSPDE4A1A