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PAK4 (Montrer PAK4 Kits ELISA) phosphorylates Par6B at Ser143 blocking its interaction with Cdc42 (Montrer CDC42 Kits ELISA).
Pard6b is necessary for blastocyst morphogenesis
found that the polarity determinants Cdc42 (Montrer CDC42 Kits ELISA), Par6B, PKCzeta (Montrer PRKCZ Kits ELISA)/iota and the structural proteins ezrin (Montrer EZR Kits ELISA) and phospho-ezrin (Montrer EZR Kits ELISA) were lost from the apical membrane and accumulated either in the cytoplasm or on the basal side of enterocytes in patients
Data conclude that Par6B and aPKC control mitotic spindle orientation in polarized epithelia and, furthermore, that aPKC coordinately regulates multiple processes to promote morphogenesis.
This study demonstrates that controlled regulation of PAK4 (Montrer PAK4 Kits ELISA) is required for apical junction formation in lung epithelial cells and highlights potential cross-talk between two Cdc42 (Montrer CDC42 Kits ELISA) targets, PAK4 (Montrer PAK4 Kits ELISA) and Par6B.
The ability of SRC (Montrer SRC Kits ELISA) family coactivators to regulate the expression of one of these genes, PARD6B/Par6, was confirmed by using cells individually depleted of SRC-1 (Montrer SRC Kits ELISA).
Interaction between PAR-3 (Montrer F2RL2 Kits ELISA) and the aPKC-PAR-6 (Montrer PARD6A Kits ELISA) complex is indispensable for apical domain development of epithelial cells.
Data indicate that the polarity protein Partitioning defective-6 homolog beta (Par6b) regulates not only the dynamics of apicobasal polarity but also integrity of the developing stratified epidermis.
ephrinB1 (Montrer EFNB1 Kits ELISA) associates with the Par (Montrer AFG3L2 Kits ELISA) polarity complex protein Par-6 (Montrer PARD6A Kits ELISA) and can compete with the small GTPase (Montrer RACGAP1 Kits ELISA) Cdc42 (Montrer CDC42 Kits ELISA) for association with Par-6.
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex.
par-6 partitioning defective 6 homolog beta (C. elegans)
, PAR-6 beta
, partitioning defective 6 homolog beta
, partitioning-defective protein 6, beta
, par-6 partitioning defective 6 homolog beta
, partitioning defective 6 beta