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Data suggest that Nrx-1 plays critical roles in regulating synaptic terminal clustering and release of synaptic vesicles of the neuromuscular junction; Nrx-1 controls terminal clustering and release of synaptic vesicles by stimulating presynaptic actin cytoskeleton assembly; Nrx-1 functions via Scribble and Pixie to activate Rac1. (Nrx-1 = neurexin-1; Rac1 = GTP-binding protein Rac1)
the simultaneous loss of the asymmetric cell division regulators Canoe (afadin (Montrer MLLT4 Kits ELISA) in mammals) and Scribble in neuroblast clones leads to tumor-like overgrowth through both a severe disruption of the asymmetric cell division process and canoe loss-mediated Ras-PI3K-Akt (Montrer AKT1 Kits ELISA) activation
the effects of loss of scrib and the modification of these effects via cooperative interactions that enhance the overall tumorigenic potential of scrib deficient cells, is reported.
Knocking down scribble expression in either Mushroom body neurons or Dopaminergic neurons impairs normal memory loss.
Our data reveal that the basolateral determinant Scribbled (Scrib) is required for PCV formation through optimizing BMP (Montrer TGFb Kits ELISA) signaling. Scrib regulates BMP (Montrer TGFb Kits ELISA)-type I receptor Thickveins (Tkv) localization at the basolateral region of PCV cells and subsequently facilitates Tkv internalization to Rab5 (Montrer RAB5A Kits ELISA) endosomes, where Tkv is active
Scrib module regulates epithelial polarity by influencing endocytic itineraries of Crumbs and other retromer-dependent cargo.
Loss of scrib, dlg (Montrer DLG4 Kits ELISA) and lgl had no effect on gonad formation, but Dlg (Montrer DLG4 Kits ELISA) and Scrib in the gonadal mesoderm acted critically in the somatic wrapping of the pole cells and the internal structure of the Drosophila embryonic gonads.
Drosophila scrib acts downstream of the Fat (Ft) receptor, and requires Hippo signaling for its growth regulatory functions.
Loss of Scrib promotes Yorkie (Montrer YAP1 Kits ELISA)/Scalloped-dependent epithelial tissue overgrowth, and this is also important for driving cooperative tumor overgrowth with oncogenic Ras-Raf (Montrer RAF1 Kits ELISA) signaling.
Data show that mutations causing the loss of Salvador (Sav (Montrer SAV1 Kits ELISA)) or Scribble (Scrib) or activation of Ras transform normal stem cells into cancer stem cells through a multistep process in the adult Drosophila Malpighian tubules.
SCRIB is a positive regulator of mammary epithelial cell proliferation during pregnancy.
Suggest a role for Plexin-B1 (Montrer PLXNB1 Kits ELISA) as a ligand and Sema4A (Montrer Sema4a Kits ELISA) as a receptor and characterize a reverse signaling pathway downstream of Sema4A (Montrer Sema4a Kits ELISA) regulating cell migration via Scrib.
SCRIB uncouples reactive oxygen species-dependent bacterial killing activity from M1 polarization and inflammatory functions of macrophages
we provide genetic evidence of a unique link between skin carcinogenesis and loss of the epithelial polarity regulator Scrib, emphasizing that Scrib exerts a wide-spread tumor suppressive function in epithelia.
The polarity protein Scribble regulates myelination and remyelination in the central nervous system.
Scrib is a regulator of tissue stem cells, controlling population expansion and self-renewal with Scrib expression dynamics directing satellite cell fate.
Scrib is a novel proinflammatory regulator in endothelial cells, which maintains the protein expression of GATA-like protein-1.
The Scrib-Rac1 interaction plays a crucial role in the organization of developing cardiomyocytes and formation of the ventricular myocardium.
We show that loss of Scrib and activated oncogenic KRas cooperate in vivo, resulting in more aggressive lung tumors
findings, based on a definitive genetic mouse model provide fundamental insights into mammary duct maturation and homeostasis and reveal that Scrib loss activates a MAPK (Montrer MAPK1 Kits ELISA)/Fra1 (Montrer FOSL1 Kits ELISA) pathway that alters mammary progenitor activity
Results demonstrate that anterior guidance decisions by commissural primary ascending (CoPA (Montrer COPA Kits ELISA)) axons are dependent on the function of planar cell polarity genes Fzd3a, Vangl2 (Montrer VANGL2 Kits ELISA) and Scribble both prior to and after midline crossing; experiments establish CoPA (Montrer COPA Kits ELISA) axons as a model system to investigate the mechanism of planar cell polarity signaling in commissural axon guidance.
Zygotic expression of Scribble1 (scrb1) is required for migration of the nVII motor neurons mainly in a non cell-autonomous manner, while maternal expression is required for convergent extension movements during gastrulation.
Suppression of scrib and puf60 (Montrer PUF60 Kits ELISA) in zebrafish leads to reduction in body length, small head size, and craniofacial defects.
It was found that Scribble is required for oriented cell division and that its function in this process is independent of canonical apicobasal and planar polarity pathways.
Lpp interacts with the PCP (Montrer PRCP Kits ELISA) protein Scrib in zebrafish, and that Lpp and Scrib cooperate for the mediation of convergence and extension.
Scribble is a candidate link between Fat and the Hippo signaling cascade in vertebrates
In this study the authors show that human Scrib expression is required for maintaining high levels of human papillomavirus type 18 E6 protein in HeLa cells.
Data suggest that Scribble PDZ-domain (Montrer INADL Kits ELISA)-1 and PDZ-domain (Montrer INADL Kits ELISA)-3 are major domains that interact with beta-PIX (Montrer ARHGEF7 Kits ELISA) and exhibit distinct binding hierarchy in interactions between individual Scribble PDZ (Montrer INADL Kits ELISA) domains and beta-PIX (Montrer ARHGEF7 Kits ELISA). (Scribble = scribbled planar cell polarity protein; beta-PIX (Montrer ARHGEF7 Kits ELISA) = Rho guanine nucleotide exchange factor 7 (Montrer ARHGEF7 Kits ELISA))
inhibiting acyl thioesterase (Montrer FASN Kits ELISA) 2 restores balance to the Scrib palmitoylation cycle, promoting membrane re-localization and growth attenuation
sequencing analysis of SCRIB1 in 473 NTD patients led to the identification of 5 rare heterozygous missense mutations that were predicted to be pathogenic. Two of these mutations, p.Gly263Ser and p.Gln808His, and 2 mouse NTD mutations, p.Ile285Lys and p.Glu814Gly, affected Scrib1 membrane localization and its modulating role of Par-3 (Montrer F2RL2 Kits ELISA) and Vangl1 (Montrer Vangl1 Kits ELISA) localization.
a new function for Scribble in Rho regulation that entails positioning of DLC3 (Montrer STARD8 Kits ELISA) GAP activity at cell junctions in polarized epithelial cells, is reported.
Low Scribble expression in the primary breast tumor was correlated to prognosis in estrogen receptor (Montrer ESR1 Kits ELISA)-positive breast cancer patients.
The Palmitoylation-deficient mutants of SCRIB were mislocalized, leading to disruption of cell polarity and loss of their tumor-suppressive activities to oncogenic YAP (Montrer YAP1 Kits ELISA), MAPK (Montrer MAPK1 Kits ELISA) and PI3K (Montrer PIK3CA Kits ELISA)/AKT (Montrer AKT1 Kits ELISA) pathways.
Data show hepatitis C virus (HCV) nonstructural protein 4B (NS4B) PDZ (Montrer INADL Kits ELISA)-binding motif (PBM) promotes the colony formation of hepatoma cells by degrading human Scribble protein.
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
, immune response deficient 15
, lethal (3) c00119
, smell impaired 97B
, PDZ-domain protein scribble
, protein scribble homolog
, scribble homolog 1
, scribbled homolog