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anti-Mouse (Murine) HAP1 Anticorps:
anti-Human HAP1 Anticorps:
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Human Monoclonal HAP1 Primary Antibody pour ICC, FACS - ABIN259097
Chan, Nasir, Gutekunst, Coleman, Maclean, Maas, Metzler, Gertsenstein, Ross, Nagy, Hayden: Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior. dans Human molecular genetics 2002
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Mouse (Murine) Monoclonal HAP1 Primary Antibody pour IF, WB - ABIN968461
Gutekunst, Li, Yi, Ferrante, Li, Hersch: The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 1998
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Human Polyclonal HAP1 Primary Antibody pour IHC, ELISA - ABIN1002402
Borrell-Pagès, Zala, Humbert, Saudou: Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies. dans Cellular and molecular life sciences : CMLS 2006
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Monoclonal HAP1 Primary Antibody pour IHC (fro), IP - ABIN534035
Gutekunst, Torre, Sheng, Yi, Coleman, Riedel, Bujo: Stigmoid bodies contain type I receptor proteins SorLA/LR11 and sortilin: new perspectives on their function. dans The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2003
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Human Polyclonal HAP1 Primary Antibody pour ELISA, WB - ABIN188689
Takeshita, Fujinaga, Zhao, Yanai, Shinoda: Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis. dans Human molecular genetics 2006
findings provide evidence that endogenous APE1 (Montrer APEX1 Anticorps) protects against ischemic infarction in both gray and white matter and facilitates the functional recovery of the central nervous system after mild stroke injury
HAP1 co-localizes with synapsin I (Montrer SYN1 Anticorps) in cortical neurons as discrete puncta
Suppression of Ape1/Ref-1 (Montrer APEX1 Anticorps) redox function leads to an increased cell surface retention of IL-12 (Montrer IL12A Anticorps) and enhances Th1 (Montrer HAND1 Anticorps) responses.
findings suggest that Hap1 is important for insulin (Montrer INS Anticorps) secretion of pancreatic beta-cells via regulating the intracellular trafficking and plasma membrane localization of Cav1.2 (Montrer CACNA1C Anticorps), providing new insight into the mechanisms that regulate insulin (Montrer INS Anticorps) release from pancreatic beta-cells.
Is closely associated with upregulation of the Ref1 (Montrer THOC4 Anticorps)/Nrf2 (Montrer NFE2L2 Anticorps) signalling pathway.
Results show the stimulatory effect of PARP-1 (Montrer PARP1 Anticorps) on APE1 (Montrer APEX1 Anticorps)-dependent base excision repair (BER). PARP-1 (Montrer PARP1 Anticorps) and APE1 (Montrer APEX1 Anticorps) appear to have a functional interaction in BER since PARP-1 (Montrer PARP1 Anticorps) can stimulate the strand incision activity of APE1 (Montrer APEX1 Anticorps).
Early loss of Hap1 significantly reduces postnatal hippocampal neurogenesis, and leads to adult depressive-like behavior.
Hap1 interacts with Bcr (Montrer BCR Anticorps) on microtubules to regulate neuronal differentiation.
increases in APEX1 (Montrer APEX1 Anticorps) level confer protection against the murine paternal age effect, thus highlighting the role of APEX1 (Montrer APEX1 Anticorps) in preserving reproductive health with increasing age and in protection against genotoxin-induced mutagenesis in somatic cells
Endothelial cell tumor proliferation was found to be dependent on Apex-1 (Montrer APEX1 Anticorps) expression.
HAP1 (Montrer APEX1 Anticorps) is expressed in endocrine cells of the human gut (Montrer GUSB Anticorps).
data fully support that HAP1 (Montrer APEX1 Anticorps) is a GKAP (Montrer DLGAP1 Anticorps), anchoring specifically to the cGMP-dependent protein kinase (Montrer CDK7 Anticorps) isoform Ibeta, and provide further evidence that also PKG (Montrer PRKG1 Anticorps) spatiotemporal signaling is largely controlled by anchoring proteins
HAP1 (Montrer APEX1 Anticorps) gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity
Overexpression of HAP1 (Montrer APEX1 Anticorps) reduced in vitro cell growth in breast cancer cell lines.
The results of this study found no association was found between the HAP1 (Montrer APEX1 Anticorps) T441M polymorphism and the age at onset of Huntington's disease .
The results of this study suggested that HAP1 (Montrer APEX1 Anticorps) co-localizes and associates with APP (Montrer APP Anticorps) in physiological conditions of mouse and human brain.
WT HTT (Montrer HTT Anticorps) regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1 (Montrer PCM1 Anticorps)).
HAP1 (Montrer APEX1 Anticorps)/stigmoid body interacts with the normal ataxin-3 (Montrer ATXN3 Anticorps) through Josephin (Montrer ATXN3 Anticorps) domain
sortilin (Montrer SORT1 Anticorps) stabilizes the proBDNF.HAP1 complex
ADORA2A (Montrer ADORA2A Anticorps), but not HAP1 (Montrer APEX1 Anticorps) or OGG1 (Montrer OGG1 Anticorps), may have a role in age at onset in Huntington's disease
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
AP endonuclease 1
, APEX nuclease
, DNA-(apurinic or apyrimidinic site) lyase
, apurinic-apyrimidinic endonuclease 1
, redox factor-1
, huntingtin-associated protein 2
, neuroan 1
, huntingtin-associated protein 1 (neuroan 1)