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findings provide evidence that endogenous APE1 (Montrer APEX1 Kits ELISA) protects against ischemic infarction in both gray and white matter and facilitates the functional recovery of the central nervous system after mild stroke injury
HAP1 co-localizes with synapsin I (Montrer SYN1 Kits ELISA) in cortical neurons as discrete puncta
Suppression of Ape1/Ref-1 (Montrer APEX1 Kits ELISA) redox function leads to an increased cell surface retention of IL-12 (Montrer IL12A Kits ELISA) and enhances Th1 (Montrer HAND1 Kits ELISA) responses.
findings suggest that Hap1 is important for insulin (Montrer INS Kits ELISA) secretion of pancreatic beta-cells via regulating the intracellular trafficking and plasma membrane localization of Cav1.2 (Montrer CACNA1C Kits ELISA), providing new insight into the mechanisms that regulate insulin (Montrer INS Kits ELISA) release from pancreatic beta-cells.
Is closely associated with upregulation of the Ref1 (Montrer THOC4 Kits ELISA)/Nrf2 (Montrer NFE2L2 Kits ELISA) signalling pathway.
Results show the stimulatory effect of PARP-1 (Montrer PARP1 Kits ELISA) on APE1 (Montrer APEX1 Kits ELISA)-dependent base excision repair (BER). PARP-1 (Montrer PARP1 Kits ELISA) and APE1 (Montrer APEX1 Kits ELISA) appear to have a functional interaction in BER since PARP-1 (Montrer PARP1 Kits ELISA) can stimulate the strand incision activity of APE1 (Montrer APEX1 Kits ELISA).
Early loss of Hap1 significantly reduces postnatal hippocampal neurogenesis, and leads to adult depressive-like behavior.
Hap1 interacts with Bcr (Montrer BCR Kits ELISA) on microtubules to regulate neuronal differentiation.
increases in APEX1 (Montrer APEX1 Kits ELISA) level confer protection against the murine paternal age effect, thus highlighting the role of APEX1 (Montrer APEX1 Kits ELISA) in preserving reproductive health with increasing age and in protection against genotoxin-induced mutagenesis in somatic cells
Endothelial cell tumor proliferation was found to be dependent on Apex-1 (Montrer APEX1 Kits ELISA) expression.
HAP1 (Montrer APEX1 Kits ELISA) is expressed in endocrine cells of the human gut (Montrer GUSB Kits ELISA).
data fully support that HAP1 (Montrer APEX1 Kits ELISA) is a GKAP (Montrer DLGAP1 Kits ELISA), anchoring specifically to the cGMP-dependent protein kinase (Montrer CDK7 Kits ELISA) isoform Ibeta, and provide further evidence that also PKG (Montrer PRKG1 Kits ELISA) spatiotemporal signaling is largely controlled by anchoring proteins
HAP1 (Montrer APEX1 Kits ELISA) gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity
Overexpression of HAP1 (Montrer APEX1 Kits ELISA) reduced in vitro cell growth in breast cancer cell lines.
The results of this study found no association was found between the HAP1 (Montrer APEX1 Kits ELISA) T441M polymorphism and the age at onset of Huntington's disease .
The results of this study suggested that HAP1 (Montrer APEX1 Kits ELISA) co-localizes and associates with APP (Montrer APP Kits ELISA) in physiological conditions of mouse and human brain.
WT HTT (Montrer HTT Kits ELISA) regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1 (Montrer PCM1 Kits ELISA)).
HAP1 (Montrer APEX1 Kits ELISA)/stigmoid body interacts with the normal ataxin-3 (Montrer ATXN3 Kits ELISA) through Josephin (Montrer ATXN3 Kits ELISA) domain
sortilin (Montrer SORT1 Kits ELISA) stabilizes the proBDNF.HAP1 complex
ADORA2A (Montrer ADORA2A Kits ELISA), but not HAP1 (Montrer APEX1 Kits ELISA) or OGG1 (Montrer OGG1 Kits ELISA), may have a role in age at onset in Huntington's disease
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
AP endonuclease 1
, APEX nuclease
, DNA-(apurinic or apyrimidinic site) lyase
, apurinic-apyrimidinic endonuclease 1
, redox factor-1
, huntingtin-associated protein 2
, neuroan 1
, huntingtin-associated protein 1 (neuroan 1)