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metabolic crosstalk is due to decreased mTORC1 and SREBP activity in PTG (Montrer LPCAT3 Kits ELISA) knockout mice or knockdown cells, suggesting a positive feedback loop in which once accumulated, glycogen (Montrer GYS1 Kits ELISA) stimulates the mTORC1/SREBP1 (Montrer SREBF1 Kits ELISA) pathway to shift energy storage to lipogenesis.
removing PTG (Montrer LPCAT3 Kits ELISA), a glycogen (Montrer GYS1 Kits ELISA) synthesis activator protein, nearly completely eliminates Lafora bodies and rescues the neurodegeneration, myoclonus,seizure susceptibility, and behavioral abnormality.
Laforin (Montrer EPM2A Kits ELISA)-deficient mice lacking PTG (Montrer LPCAT3 Kits ELISA) have greatly decreased Lafora bodies and normal glycogen (Montrer GYS1 Kits ELISA) levels.
These data suggest that PTG (Montrer LPCAT3 Kits ELISA) plays a critical role in glycogen (Montrer GYS1 Kits ELISA) synthesis and is necessary to maintain the appropriate metabolic balance for the partitioning of fuel substrates between glycogen (Montrer GYS1 Kits ELISA) and lipid.
PTG (Montrer LPCAT3 Kits ELISA) overexpression in 3T3-L1 adipocytes discretely stimulates PP1 (Montrer PPP1CC Kits ELISA) activity against glycogen synthase and phosphorylase, resulting in a marked and specific increase in glucose uptake and storage as glycogen (Montrer GYS1 Kits ELISA).
These data indicate that disruption of PTG (Montrer LPCAT3 Kits ELISA) expression resulted in the uncoupling of PP1 (Montrer PPP1CC Kits ELISA) activity from glycogen (Montrer GYS1 Kits ELISA) metabolizing enzymes, the enhancement of glycogenolysis, and a dramatic decrease in cellular glycogen (Montrer GYS1 Kits ELISA) levels.
mouse protein targeting to glycogen (PTG) promoter is regulated by the FoxA2 (Montrer FOXA2 Kits ELISA) forkhead protein (Montrer FOXO4 Kits ELISA) and by 3',5'-cyclic adenosine 5'-monophosphate in H4IIE hepatoma cells
PPP1R3C, a novel hypermethylated gene in colorectal cancer, may play a critical role in cancer cell growth in association with glucose levels.
detection of methylation of PPP1R3C alone or in combination with EFHD1 (Montrer EFHD1 Kits ELISA) in plasma DNA showed high sensitivity and specificity in CRC (Montrer CALR Kits ELISA) detection, and may be useful detection method for CRC (Montrer CALR Kits ELISA), especially for early-stage CRCs.
Findings suggest that variations in PTG may condition the course of Lafora disease and establish PTG as a potential target for pharmacogenetic and therapeutic approaches.
Results demonstrated that HIF1 (Montrer HIF1A Kits ELISA) promotes glycogen (Montrer GYS1 Kits ELISA) accumulation through regulating PPP1R3C expression under hypoxia, which revealed a novel metabolic adaptation of cells to hypoxia.
phosphorylation of R5/PTG at Ser (Montrer SIGLEC1 Kits ELISA)-8 by AMPK (Montrer PRKAA1 Kits ELISA) accelerates its laforin (Montrer EPM2A Kits ELISA)/malin (Montrer NHLRC1 Kits ELISA)-dependent ubiquitination and subsequent proteasomal degradation, which results in a decrease of its glycogenic activity.
This gene encodes a regulatory subunit of protein phosphatase-1 (PP1). PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities: neuronal, muscular, RNA splicing, protein synthesis, cell death, and glycogen metabolism, to name just a few. By interacting with different regulatory subunits, PP1 is directed to different parts of the cell, to different substrates, or to respond to extracellular signals.
PP1 subunit R5
, protein phosphatase 1 binding protein PTG
, protein phosphatase 1 regulatory subunit 3C
, protein phosphatase 1 regulatory subunit 5
, protein phosphatase 1, regulatory (inhibitor) subunit 5
, protein targeting to glicogen
, protein targeting to glycogen
, Phosphatase 1, regulatory inhibitor subunit 5
, protein phosphatase 1, regulatory (inhibitor) subunit 3C