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Our data demonstrated that Ctr9, independent of other PAFc subunits, controls ERalpha-target gene expression by regulating global chromatin occupancies of ERalpha and RNAPII.
Ctr9, a key subunit of hPAFc, is a central regulator of estrogen signaling that drives ERalpha (Montrer ESR1 Kits ELISA)(+) breast tumorigenesis
Ctr9, formerly identified as a nuclei protein, interacts with the dopamine transporter in the cytoplasmic compartment.
CTR9 is a PAF1 (Montrer PEX2 Kits ELISA) complex gene whose germline mutations predispose to Wilms tumour
CTR9, a component of PAF complex, controls elongation block at the c-Fos locus via signal-dependent regulation of chromatin-bound NELF dissociation.
MLL (Montrer MLL Kits ELISA) interacts directly with the polymerase associated factor complex (PAFc) via Paf1 (Montrer PEX2 Kits ELISA) and CTR9. PAFc augments MLL (Montrer MLL Kits ELISA) and MLL (Montrer MLL Kits ELISA)-AF9 (Montrer MLLT3 Kits ELISA) mediated transcriptional activation of Hoxa9 (Montrer HOXA9 Kits ELISA) and their interaction is essential for leukemogenesis.
CTR9 participates in the transcription of IL-6 (Montrer IL6 Kits ELISA)-responsive genes through the regulation of DNA association of STAT3 (Montrer STAT3 Kits ELISA) and modification of histone methylation
our data suggest that Setd5 is required for maintaining PGC (Montrer PGC Kits ELISA)-associated genes and Setd5-associated protein complexes containing Tbl1xr1 (Montrer TBL1XR1 Kits ELISA) and Ctr9, which in turn are likely involved in regulating germ cell-related genes in mESCs
these data propose a novel feed-forward loop of IL-17 (Montrer IL17A Kits ELISA) transcriptional regulatory circuit, via IL-6 (Montrer IL6 Kits ELISA)-mediated repression of CTR9 which is a transcriptional repressor of IL-17 (Montrer IL17A Kits ELISA).
CTR9, parafibromin (CDC73\; MIM 607393), LEO1 (MIM 610507), and PAF1 (MIM 610506) form the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005
Ctr9, Paf1/RNA polymerase II complex component, homolog
, RNA polymerase-associated protein CTR9 homolog
, SH2 domain binding protein 1 (tetratricopeptide repeat containing)
, SH2 domain-binding protein 1
, TPR-containing, SH2-binding phosphoprotein
, TPR-containing, SH2-binding phosphoprotein of 150 kDa
, tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa
, Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
, SH2 domain binding protein 1